Wun-Jae Kim

TL;DR: The signature of E2F1–EZH2–SUZ12–driven transcriptional events may regulate the cancer aggressiveness and chemo-resistance, which may provide opportunity for development of new treatment modalities.

TL;DR: The results of this study suggest that these novel methylation markers are independent prognostic indicators in N MIBC patients, which may facilitate the assessment of disease recurrence and progression in NMIBC patients and inform clinical decision making regarding treatment.

TL;DR: The data indicate that genistein may attenuate the initiation of intracellular signaling cascades by LPS through inhibiting NF-κB activation by inhibiting the binding of LPS to TLR-4 on microglial cells.

TL;DR: It is demonstrated that the Ras/Raf/ERK pathway participates in p21WAF1 induction, subsequently leading to a decrease in the levels of cyclin D1/CDK4 and cyclin E-CDK2 complexes and naringin-dependent inhibition of cell growth.

TL;DR: Treatment with a combination of TRAIL and naringenin may be a safe strategy for treatment of resistant NSCLC with no detectable inhibitory effects on cell proliferation of normal lung fibroblast cells.