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Xianzhong Xiao
Researcher at Central South University
Publications - 159
Citations - 6693
Xianzhong Xiao is an academic researcher from Central South University. The author has contributed to research in topics: Apoptosis & Sepsis. The author has an hindex of 36, co-authored 155 publications receiving 5404 citations. Previous affiliations of Xianzhong Xiao include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice
Xianzhong Xiao,Xiaoxia Zuo,Alberta A. Davis,D. Randy McMillan,Bishop B. Curry,James A. Richardson,Ivor J. Benjamin +6 more
TL;DR: Direct causal effects for the HSF1 transactivator in regulating critical physiological events during extra‐embryonic development and under pathological conditions such as sepsis to modulate pro‐inflammatory responses are established, indicating that these pathways have clinical importance as therapeutic targets in humans.
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Targeted Disruption of Heat Shock Transcription Factor 1 Abolishes Thermotolerance and Protection against Heat-inducible Apoptosis
TL;DR: It is concluded that 1) constitutive and inducibly expressed HSPs exhibit distinct physiological functions for cellular maintenance and adaptation, respectively, and 2) other mammalian HSFs or distinct evolutionarily conserved stress response pathways do not compensate for HSF1 in the physiological response to heat shock.
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The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis
Meihong Deng,Yiting Tang,Wenbo Li,Xiangyu Wang,Rui Zhang,Xianying Zhang,Xin Zhao,Jian Liu,Cheng Tang,Zhonghua Liu,Yongzhuo Huang,Huige Peng,Lehui Xiao,Daolin Tang,Melanie J. Scott,Qingde Wang,Jing Liu,Xianzhong Xiao,Simon C. Watkins,Jianhua Li,Huan Yang,Haichao Wang,Fangping Chen,Kevin J. Tracey,Timothy R. Billiar,Ben Lu +25 more
TL;DR: It is demonstrated that hepatocyte‐released HMGB1 mediates caspase‐11‐dependent pyroptosis and lethality in sepsis by delivering extracellular LPS into the cytosol of macrophages and endothelial cells, where LPS activates casp enzyme‐11.
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Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1
Daolin Tang,Yongzhong Shi,Rui Kang,Tong Li,Weimin Xiao,Weimin Xiao,Haichao Wang,Xianzhong Xiao +7 more
TL;DR: It is demonstrated that a reactive oxygen species, hydrogen peroxide (H2O2), induces active and passive HMGB1 release from macrophage and monocyte cultures in a time‐ and dose‐dependent manner and establishes an important role for oxidative stress in inducing active HMGB 1 release.
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Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage
Liang-Jun Yan,Elisabeth S. Christians,Li Liu,Xianzhong Xiao,Rajindar S. Sohal,Ivor J. Benjamin +5 more
TL;DR: The results indicate for the first time that constitutive expression of HSP chaperones requires HSF1 activity, and that suchHSF1‐dependent requirements are directly and functionally linked to maintain redox homeostasis and antioxidative defenses at normal (37°C) temperature.