Jay Rappaport

TL;DR: In this article, the authors demonstrate the capacity of a subunit vaccine, comprising the SARS-CoV-2 spike protein receptor-binding domain displayed on an I53-50 protein nanoparticle scaffold (hereafter designated RBD-NP), to stimulate robust and durable neutralizing-antibody responses.

TL;DR: Interestingly, SARS-CoV-2 infection downregulates ACE2 expression, which may also play a critical pathogenic role in COVID-19, and targeting ACE2/Ang 1-7 axis and blocking ACE2 interaction with the S protein of Sars-Cov-2 to curtail SARV- CoV- 2 infection are becoming very attractive therapeutics potential for treatment and prevention of CO VID-19.

TL;DR: An isolation-free smartphone-based saliva assay that can diagnose COVID-19 cases and quantify viral load within 15 min and exhibited a limit of detection below that of the RT-PCR reference assay is described.

TL;DR: This work reports ARDS in two aged African green monkeys infected with SARS-CoV-2 that demonstrated pathological lesions and disease similar to severe COVID-19 in humans and suggests that aged AGMs may be useful for modeling severe disease manifestations including ARDS.

TL;DR: In this article, the authors showed that SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis and increased pulmonary vascular permeability leading to edema and hemorrhage.