A
Anna Jinxia Zhang
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 37
Citations - 3181
Anna Jinxia Zhang is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 19 publications receiving 1779 citations.
Papers
More filters
Journal ArticleDOI
Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility.
Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Anna Jinxia Zhang,Shuofeng Yuan,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Andrew Chak-Yiu Lee,Wan Mui Chan,Zhimeng Fan,Hoi Wah Tsoi,Lei Wen,Ronghui Liang,Jianli Cao,Yanxia Chen,Kaiming Tang,Cuiting Luo,Jian Piao Cai,Kin-Hang Kok,Hin Chu,Kwok-Hung Chan,Siddharth Sridhar,Siddharth Sridhar,Siddharth Sridhar,Zhiwei Chen,Honglin Chen,Kelvin K. W. To,Kelvin K. W. To,Kelvin K. W. To,Kwok-Yung Yuen,Kwok-Yung Yuen,Kwok-Yung Yuen +31 more
TL;DR: Besides satisfying the Koch’s postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2.
Journal ArticleDOI
Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19.
Hin Chu,Jasper Fuk-Woo Chan,Yixin Wang,Terrence Tsz-Tai Yuen,Yue Chai,Yuxin Hou,Huiping Shuai,Dong Yang,Bingjie Hu,Xiner Huang,Xi Zhang,Jian-Piao Cai,Jie Zhou,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Kelvin K. W. To,Ivy Hau-Yee Chan,Anna Jinxia Zhang,Ko-Yung Sit,Wing-Kuk Au,Kwok-Yung Yuen +22 more
TL;DR: This study provided the first quantitative data on the comparative replication capacity and immune activation profile of SARS-CoV-2 and SARS -CoV infection in human lung tissues and provided important insights on the pathogenesis, high transmissibility, and asymptomatic infection of Sars-Cov-2.
Journal ArticleDOI
Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19).
Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Shuofeng Yuan,Anna Jinxia Zhang,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Andrew Chak-Yiu Lee,Zhimeng Fan,Can Li,Ronghui Liang,Jianli Cao,Kaiming Tang,Cuiting Luo,Vincent C.C. Cheng,Jian-Piao Cai,Hin Chu,Kwok-Hung Chan,Kelvin K. W. To,Kelvin K. W. To,Kelvin K. W. To,Siddharth Sridhar,Siddharth Sridhar,Siddharth Sridhar,Kwok-Yung Yuen,Kwok-Yung Yuen,Kwok-Yung Yuen +26 more
TL;DR: SARS-CoV-2 could be transmitted by respiratory droplets or airborne droplet nuclei in the hamster model and such transmission could be reduced by surgical mask usage, especially when masks were worn by infected individuals.
Journal ArticleDOI
Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction.
Siu Ying Lau,Pui Wang,Bobo Wing-Yee Mok,Anna Jinxia Zhang,Hin Chu,Andrew Chak-Yiu Lee,Shaofeng Deng,Pin Chen,Kwok-Hung Chan,Wenjun Song,Zhiwei Chen,Kelvin K. W. To,Jasper Fuk-Woo Chan,Kwok-Yung Yuen,Honglin Chen +14 more
TL;DR: Infection of hamsters shows that one of the variants which carries deletion of 10 amino acids does not cause the body weight loss or more severe pathological changes in the lungs that is associated with wild type virus infection, and it is suggested that the unique cleavage motif promoting SARS-CoV-2 infection in humans may be under strong selective pressure.
Journal ArticleDOI
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Shuofeng Yuan,Shuofeng Yuan,Xin Yin,Xin Yin,Xiangzhi Meng,Jasper Fuk-Woo Chan,Zi-Wei Ye,Laura Riva,Laura Riva,Lars Pache,Chris Chun-Yiu Chan,Pok Man Lai,Chris Chung-Sing Chan,Vincent Kwok-Man Poon,Andrew Chak-Yiu Lee,Naoko Matsunaga,Yuan Pu,Chun-Kit Yuen,Jianli Cao,Ronghui Liang,Kaiming Tang,Li Sheng,Li Sheng,Yushen Du,Wan Xu,Chit-Ying Lau,Ko-Yung Sit,Wing-Kuk Au,Runming Wang,Yu-Yuan Zhang,Yan-Dong Tang,Thomas Mandel Clausen,Thomas Mandel Clausen,Jessica Pihl,Jessica Pihl,Juntaek Oh,Juntaek Oh,Kong-Hung Sze,Anna Jinxia Zhang,Hin Chu,Kin-Hang Kok,Dong Wang,Dong Wang,Xue-Hui Cai,Jeffrey D. Esko,Ivan Hung,Ronald A. Li,Honglin Chen,Hongzhe Sun,Dong-Yan Jin,Ren Sun,Ren Sun,Sumit K. Chanda,Kwok-Yung Yuen +53 more
TL;DR: In this paper, the authors show that clofazimine-an anti-leprosy drug with a favorable safety profile-possesses inhibitory activity against several coronaviruses, and can antagonize the replication of SARS-CoV-2 and MERS-coV in a range of in vitro systems.