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Xiaoli Zhang
Researcher at University of Michigan
Publications - 58
Citations - 4066
Xiaoli Zhang is an academic researcher from University of Michigan. The author has contributed to research in topics: Lysosome & Autophagy. The author has an hindex of 24, co-authored 54 publications receiving 3034 citations. Previous affiliations of Xiaoli Zhang include Georgia State University & Northwestern Polytechnical University.
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Journal ArticleDOI
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Xiang Wang,Xiaoli Zhang,Xian-Ping Dong,Mohammad Samie,Xinran Li,Xiping Cheng,Andrew Goschka,Dongbiao Shen,Yandong Zhou,Janice Harlow,Michael X. Zhu,David E. Clapham,Dejian Ren,Haoxing Xu +13 more
TL;DR: It is shown that, in contrast to previous conclusions, TPCs are in fact sodium-selective channels activated by PI(3,5)P(2) and are not activated by NAADP, and the primary endolysosomal ion is Na(+), not K(+, as had been previously assumed.
Journal ArticleDOI
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
Dongbiao Shen,Xiang Wang,Xinran Li,Xiaoli Zhang,Zepeng Yao,Shannon Dibble,Xian-Ping Dong,Ting Yu,Andrew P. Lieberman,H. D. Hollis Showalter,Haoxing Xu +10 more
TL;DR: In NP-type C cells, increasing TRPML1's expression or activity was sufficient to correct the trafficking defects and reduce lysosome storage and cholesterol accumulation, and it is proposed that abnormal accumulation of luminal lipids causes secondary lysOSome storage by blocking TRP ML1- and Ca(2+)-dependent lyssomal trafficking.
Journal ArticleDOI
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
Xiaoli Zhang,Xiping Cheng,Lu Yu,Junsheng Yang,Junsheng Yang,Raul Calvo,Samarjit Patnaik,Xin Hu,Qiong Gao,Meimei Yang,Maria Lawas,Markus Delling,Juan J. Marugan,Marc Ferrer,Haoxing Xu +14 more
TL;DR: It is shown that reactive oxygen species (ROS) activate TFEB via a lysosomal Ca2+-dependent mechanism independent of mTOR, which triggers calcineurin-dependent T FEB-nuclear translocation, autophagy induction and lysOSome biogenesis.
Journal ArticleDOI
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
Xinran Li,Nicholas R. Rydzewski,Ahmad Hider,Xiaoli Zhang,Junsheng Yang,Wuyang Wang,Qiong Gao,Xiping Cheng,Haoxing Xu +8 more
TL;DR: It is shown that TRPML1 activity is required to promote Ca2+-dependent centripetal movement of lysosomes towards the perinuclear region (where autophagosomes accumulate) following autophagy induction.
Journal ArticleDOI
A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
Mohammad Samie,Xiang Wang,Xiaoli Zhang,Andrew Goschka,Xinran Li,Xiping Cheng,Evan Gregg,Marlene Azar,Yue Zhuo,Abigail G. Garrity,Qiong Gao,Susan A. Slaugenhaupt,Jim Pickel,Sergey N. Zolov,Lois S. Weisman,Guy M. Lenk,Steve Titus,Marthe Bryant-Genevier,Noel Southall,Marugan Juan,Marc Ferrer,Haoxing Xu +21 more
TL;DR: Phagocytic ingestion of large particles activates a phosphoinositide- and Ca2+-dependent exocytosis pathway to provide membranes necessary for pseudopod extension, leading to clearance of senescent and apoptotic cells in vivo.