Xing Gong

TL;DR: The administration of certain toll-like receptor (TLR) ligands, via the activation of innate immunity, induces high levels of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of tryptophan catabolism in various organs.

TL;DR: This article has been retracted at the request of the authors because the anti-IKKα (IB) loading controls presented in Figures 3A, 3B, 3C, and 4C are duplicate presentations of the same gel lanes and do not represent the correct controls for the individual experiments.

TL;DR: It is reported that HAA inhibits NF-κB activation upon T cell antigen receptor engagement by specifically targeting PDK1, and is a natural inhibitor that restrains T cell expansion and activation.

TL;DR: This study identifies T α1 as a unique activator of the TRAF6 signal pathway and provides a cohesive interpretation of the molecular basis of the therapeutic utility of Tα1.

TL;DR: A mouse model developed provides a mechanistic insight into Th2 phenotype spread and offers an animal model for testing relevant immunomodulatory interventions.