Xingqun Liang

TL;DR: Two sets of cardiogenic precursors are defined, one of which expresses and requires Isl1 and the other of which does not, which have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells.

TL;DR: The identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ is reported, which provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.

TL;DR: The data indicate that Isl1 is a specific marker for a subset of pacemaker cells at developmental stages examined, and suggest genetic heterogeneity within the central conduction system and coronary smooth muscle.

TL;DR: Mechanistic studies demonstrated that four-and-a-half LIM domains 1 (FHL1) plays an important role in the mechanism of pathological hypertrophy by sensing biomechanical stress responses via the N2B stretch sensor domain of titin and initiating changes in the titin- and MAPK-mediated responses important for sarcomere extensibility and intracellular signaling.

TL;DR: A central role for Islet1 is established in the transition from sensory neurogenesis to subtype specification as well as prolonged expression of developmental regulators and ectopic expression of transcription factors that are normally found in the CNS, but not in sensory ganglia.