L
Lianchun Wang
Researcher at University of South Florida
Publications - 72
Citations - 5886
Lianchun Wang is an academic researcher from University of South Florida. The author has contributed to research in topics: Heparan sulfate & Heparin. The author has an hindex of 32, co-authored 72 publications receiving 5244 citations. Previous affiliations of Lianchun Wang include University of California, San Diego & University of Georgia.
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Journal ArticleDOI
A myocardial lineage derives from Tbx18 epicardial cells
Chen-Leng Cai,Jody Martin,Yunfu Sun,Li Cui,Lianchun Wang,Kunfu Ouyang,Lei Yang,Lei Bu,Xingqun Liang,Xiaoxue Zhang,William B. Stallcup,Christopher P. Denton,Andrew D. McCulloch,Ju Chen,Sylvia M. Evans +14 more
TL;DR: The identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ is reported, which provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.
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Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
Nan Tang,Lianchun Wang,Jeffrey D. Esko,Frank J. Giordano,Yan Huang,Hans-Peter Gerber,Napoleone Ferrara,Randall S. Johnson +7 more
TL;DR: It is found that loss of HIF-1alpha inhibits a number of important parameters of EC behavior during angiogenesis: these include proliferation, chemotaxis, extracellular matrix penetration, and wound healing.
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Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.
TL;DR: In this article, the involvement of endothelial heparan sulfate in inflammation by inactivating the enzyme Nacetyl glucosamine N-deacetylase-N-sulfotransferase-1 in endothelial cells and leukocytes was studied.
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Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
Bin Zhou,Leah B. Honor,Huamei He,Qing Ma,Jin-Hee Oh,Jin-Hee Oh,Catherine Butterfield,Ruei-Zeng Lin,Juan M. Melero-Martin,Elena Dolmatova,Heather S. Duffy,Alexander von Gise,Pingzhu Zhou,Yong Wu Hu,Gang Wang,Bing Zhang,Lianchun Wang,Jennifer L. Hall,Marsha A. Moses,Francis X. McGowan,William T. Pu +20 more
TL;DR: Genetic fate-mapping approaches in mice indicate that epicardium modulates the cardiac injury response by conditioning the subepicardial environment, potentially offering a new therapeutic strategy for cardiac protection.
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Heparin’s anti-inflammatory effects require glucosamine 6- O -sulfation and are mediated by blockade of L- and P-selectins
TL;DR: Heparin's anti-inflammatory effects are mainly mediated by blocking P- and L-selectin-initiated cell adhesion; the sulfate groups at C6 on the glucosamine residues play a critical role in selectin inhibition; and some non-anticoagulant forms of heparin retain anti- inflammatory activity.