Xuan Wang-Kan

TL;DR: Recent advances that have increased understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria are described, suggesting opportunities for countering their activities.

TL;DR: Loss of AcrB efflux function causes loss of virulence in Salmonella enterica serovar Typhimurium and the data suggest that gene deletion mutants are unsuitable for studying membrane transporters and, importantly, that inhibitors of AcRB Efflux function will not induce expression of other RND pumps.

TL;DR: It is shown that an efflux pump inhibitor potentiates antibiotic activity by restraining drug-binding pocket dynamics, rather than preventing antibiotic binding, and it is revealed that a drug- binding pocket substitution discovered within a multidrug resistant clinical isolate modifies the plasticity of the transport pathway, which could explain its altered substrate efflux.

TL;DR: A ZBP1-RIPK3- RIPK1-mediated inflammatory signaling pathway relayed by the scaffolding role of RIPKs and regulated by caspases is described, which may induce inflammation when Z BP1 is activated below the threshold needed to trigger a cell death response.

TL;DR: In this article, the authors analyzed the native substrate profile of AcrB in Escherichia coli MG1655 and Salmonella enterica serovar Typhimurium SL1344 using an untargeted metabolomics approach.