D
Dijun Du
Researcher at University of Cambridge
Publications - 25
Citations - 2072
Dijun Du is an academic researcher from University of Cambridge. The author has contributed to research in topics: Efflux & Bacterial outer membrane. The author has an hindex of 15, co-authored 25 publications receiving 1585 citations. Previous affiliations of Dijun Du include ShanghaiTech University & Durham University.
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Journal ArticleDOI
Structure of the AcrAB–TolC multidrug efflux pump
Dijun Du,Zhao Wang,Nathan R. James,Jarrod E. Voss,Ewa Klimont,Thelma Ohene-Agyei,Henrietta Venter,Wah Chiu,Ben F. Luisi +8 more
TL;DR: The pseudo-atomic structure of a complete multidrug efflux pump in complex with a modulatory protein partner from E. coli is presented, which defines the quaternary organization of the pump, identifies key domain interactions, and suggests a cooperative process for channel assembly and opening.
Journal ArticleDOI
Multidrug efflux pumps: structure, function and regulation
Dijun Du,Xuan Wang-Kan,Arthur Neuberger,Hendrik W. van Veen,Klaas M. Pos,Laura J. V. Piddock,Ben F. Luisi +6 more
TL;DR: Recent advances that have increased understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria are described, suggesting opportunities for countering their activities.
Journal ArticleDOI
An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.
Zhao Wang,Guizhen Fan,Corey F. Hryc,James N. Blaza,Irina I. Serysheva,Michael F. Schmid,Wah Chiu,Ben F. Luisi,Dijun Du +8 more
TL;DR: The near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states are reported, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening.
Journal ArticleDOI
Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.
Anthony W. P. Fitzpatrick,Salomé Llabrés,Arthur Neuberger,James N. Blaza,Xiao Chen Bai,Ui Okada,Satoshi Murakami,Hendrik W. van Veen,Ulrich Zachariae,Sjors H.W. Scheres,Ben F. Luisi,Dijun Du +11 more
TL;DR: In this article, an electron-cryo-microscopy structure of the ABC-type tripartite assembly of Escherichia coli was presented at near-atomic resolution.
Journal ArticleDOI
Structure, mechanism and cooperation of bacterial multidrug transporters.
TL;DR: The current models for the transport mechanisms for the main classes of multi-drug transporters and their higher-order assemblies for Gram-negative bacteria are presented.