Yajia Zhang

TL;DR: An exome capture RNA sequencing protocol is used to detect and characterize circRNAs across >2,000 cancer samples and built the most comprehensive catalog of circRNA species to date, MiOncoCirc, the first database to be composed primarily of circ RNAs directly detected in tumor tissues.

TL;DR: ARLNC1 is a newly discovered lncRNA that is induced by androgen receptor (AR) and maintains AR signaling by stabilizing the AR transcript and is identified as a novel therapeutic target.

TL;DR: It is demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to interferon (IFN) responsive genes, caused impaired IFN-gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies as well as in murine cancer models.

TL;DR: The first comprehensive molecular PeSCCA analysis is provided, which offers new insight into potential precision medicine approaches for this disease, including strategies targeting EGFR.

TL;DR: MechRNA is introduced, a pipeline for corroborating RNA–RNA interaction prediction and protein binding prediction for identifying possible lncRNA mechanisms involving specific targets or on a transcriptome-wide scale, allowing for large-scale analysis of lnc RNA interactions with little or no loss of optimality.