S
Sudhanshu Shukla
Researcher at Indian Institutes of Technology
Publications - 39
Citations - 2210
Sudhanshu Shukla is an academic researcher from Indian Institutes of Technology. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 20, co-authored 33 publications receiving 1468 citations. Previous affiliations of Sudhanshu Shukla include University of Michigan & Indian Institute of Science.
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Journal ArticleDOI
The Landscape of Circular RNA in Cancer.
Josh N. Vo,Marcin Cieslik,Yajia Zhang,Sudhanshu Shukla,Sudhanshu Shukla,Lanbo Xiao,Yuping Zhang,Yi-Mi Wu,Saravana M. Dhanasekaran,Carl G. Engelke,Xuhong Cao,Dan R. Robinson,Alexey I. Nesvizhskii,Arul M. Chinnaiyan +13 more
TL;DR: An exome capture RNA sequencing protocol is used to detect and characterize circRNAs across >2,000 cancer samples and built the most comprehensive catalog of circRNA species to date, MiOncoCirc, the first database to be composed primarily of circ RNAs directly detected in tumor tissues.
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Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression
Yajia Zhang,Sethuramasundaram Pitchiaya,Marcin Cieślik,Yashar S. Niknafs,Jean C.-Y. Tien,Yasuyuki Hosono,Matthew K. Iyer,Sahr Yazdani,Shruthi Subramaniam,Sudhanshu Shukla,Sudhanshu Shukla,Xia Jiang,Lisha Wang,Tzu-Ying Liu,Michael Uhl,Alexander R. Gawronski,Yuanyuan Qiao,Lanbo Xiao,Saravana M. Dhanasekaran,Kristin M. Juckette,Lakshmi P. Kunju,Xuhong Cao,Utsav Patel,Mona Batish,Mona Batish,Girish C. Shukla,Michelle T. Paulsen,Mats Ljungman,Hui Jiang,Rohit Mehra,Rolf Backofen,Cenk Sahinalp,Cenk Sahinalp,Susan M. Freier,Andrew T. Watt,Shuling Guo,John T. Wei,Felix Y. Feng,Rohit Malik,Rohit Malik,Arul M. Chinnaiyan +40 more
TL;DR: ARLNC1 is a newly discovered lncRNA that is induced by androgen receptor (AR) and maintains AR signaling by stabilizing the AR transcript and is identified as a novel therapeutic target.
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Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma
Sudhanshu Shukla,Joseph R. Evans,Rohit Malik,Felix Y. Feng,Saravana M. Dhanasekaran,Xuhong Cao,Guoan Chen,David G. Beer,Hui Jiang,Arul M. Chinnaiyan +9 more
TL;DR: The first prognostic analysis of lung adenocarcinoma RNA-seq data and generated a four-gene prognostic signature that can provide a powerful prognostic tool for precision oncology as part of an integratedRNA-seq clinical sequencing program is presented.
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ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer
Kiran Mahajan,Pavani Malla,Harshani R. Lawrence,Zhihua Chen,Chandan Kumar-Sinha,Rohit Malik,Sudhanshu Shukla,Jongphil Kim,Domenico Coppola,Nicholas J. Lawrence,Nupam P. Mahajan +10 more
TL;DR: A feedforward ACK1/pY88-H4/WDR5/MLL2/AR epigenetic circuit drives CRPC and is necessary for maintenance of the malignant state.
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Methylation Silencing of ULK2, An Autophagy Gene, is Essential for Astrocyte Transformation and Tumor Growth
Sudhanshu Shukla,Irene Rosita Pia Patric,Vikas Patil,S D Shwetha,Alangar S. Hegde,Bangalore A. Chandramouli,Arimappamagan Arivazhagan,Vani Santosh,Kumaravel Somasundaram +8 more
TL;DR: The results altogether suggest that inhibition of autophagy by ULK1/2 down-regulation is essential for glioma development.