Y
Yan Ting Zhao
Researcher at University of Washington
Publications - 12
Citations - 244
Yan Ting Zhao is an academic researcher from University of Washington. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 4, co-authored 7 publications receiving 53 citations.
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Journal ArticleDOI
Designed proteins assemble antibodies into modular nanocages.
Robby Divine,Ha V. Dang,George Ueda,Jorge A. Fallas,Ivan Vulovic,William Sheffler,Shally Saini,Yan Ting Zhao,Infencia Xavier Raj,Peter A. Morawski,Madeleine F. Jennewein,Leah J. Homad,Yu Hsin Wan,Marti R. Tooley,Franziska Seeger,Ali Etemadi,Ali Etemadi,Mitchell L Fahning,James Lazarovits,Alex Roederer,Alexandra C. Walls,L. Stewart,Mohammadali Mazloomi,Neil P. King,Daniel J. Campbell,Andrew T. McGuire,Andrew T. McGuire,Leonidas Stamatatos,Leonidas Stamatatos,Hannele Ruohola-Baker,Julie Mathieu,David Veesler,David Baker +32 more
TL;DR: In this article, the computational design of nanocages in which one structural component is an antibody or Fc-ligand fusion and the second is a designed antibody-binding homo-oligomer that drives nanocage assembly is discussed.
Journal ArticleDOI
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice
Andrew C. Hunt,James Brett Case,Young-Jun Park,Longxing Cao,K.-P. Wu,Alexandra C. Walls,Zhuoming Li,John E. Bowen,Hsien-Wei Yeh,Shally Saini,Louisa Helms,Yan Ting Zhao,Tien-Ying Hsiang,Tyler N. Starr,Inna Goreshnik,Lisa Kozodoy,Lauren Carter,Rashmi Ravichandran,Lydia Green,Wadim L. Matochko,Christy A. Thomson,Bastian Vögeli,Antje Krüger,Laura A. VanBlargan,Rita E. Chen,Baoling Ying,Adam L. Bailey,Natasha M. Kafai,Scott E. Boyken,Ajasja Ljubetič,Natasha Edman,George Ueda,Cameron M. Chow,Max Johnson,Amin Addetia,Mary Jane Navarro,Nuttada Panpradist,Michael Gale,Benjamin S. Freedman,Jesse D. Bloom,Hannele Ruohola-Baker,Sean P. J. Whelan,Lance Stewart,Michael S. Diamond,David Veesler,Michael C. Jewett,D. Baker +46 more
TL;DR: Computationally designed trivalent minibinders provide therapeutic protection in mice against emerging SARS-CoV-2 variants of concern and support further investigation into multivalent minibinder as therapeutic agents for Sars-Cov-2.
Journal ArticleDOI
Metabolism as an early predictor of DPSCs aging
Dannie Macrin,Ammar Alghadeer,Yan Ting Zhao,Jason W. Miklas,Abdiasis M. Hussein,Damien Detraux,Aaron M. Robitaille,Anup Madan,Randall T. Moon,Yuliang Wang,Arikketh Devi,Arikketh Devi,Julie Mathieu,Hannele Ruohola-Baker +13 more
TL;DR: Using metabolic flux analysis, this study identifies Barx1 as a DPSCs marker and dissects the first predictive metabolic signature for DPSCs aging, indicating a loss of stem cell characteristics and spontaneous initiation of terminal differentiation.
Posted ContentDOI
Designed proteins assemble antibodies into modular nanocages
Robby Divine,Ha V. Dang,George Ueda,Jorge A. Fallas,Ivan Vulovic,William Sheffler,Shally Saini,Yan Ting Zhao,Infencia Xavier Raj,Peter A. Morawski,Madeleine F. Jennewein,Leah J. Homad,Yu Hsin Wan,Marti R. Tooley,Franziska Seeger,Ali Etemadi,Ali Etemadi,Mitchell L Fahning,James Lazarovits,Alex Roederer,Alexandra C. Walls,L. Stewart,Mohammadali Mazloomi,Neil P. King,Daniel J. Campbell,Andrew T. McGuire,Andrew T. McGuire,Leonidas Stamatatos,Leonidas Stamatatos,Hannele Ruohola-Baker,Julie Mathieu,David Veesler,David Baker,David Baker +33 more
TL;DR: It is anticipated that the ability to assemble arbitrary antibodies without need for covalent modification into highly ordered assemblies with different geometries and valencies will have broad impact in biology and medicine.
Posted ContentDOI
F-domain valency determines outcome of signaling through the angiopoietin pathway.
Yan Ting Zhao,Jorge A. Fallas,Shally Saini,George Ueda,Logeshwaran Somasundaram,Ziben Zhou,Infencia Raj Xavier,Devon Ehnes,Chunfu Xu,Lauren Carter,Samuel Wrenn,Julie Mathieu,Drew L. Sellers,David Baker,Hannele Ruohola-Baker +14 more
TL;DR: The protein kinase activation and morphological phenotypes produced by a series of computationally designed protein scaffolds presenting the Ang1 F-domain in a wide range of valencies and geometries are examined to investigate the molecular basis for the opposing effects of Ang1 and Ang2.