Y
Yuliang Wang
Researcher at University of Washington
Publications - 55
Citations - 2340
Yuliang Wang is an academic researcher from University of Washington. The author has contributed to research in topics: Cancer & Induced pluripotent stem cell. The author has an hindex of 19, co-authored 47 publications receiving 1639 citations. Previous affiliations of Yuliang Wang include Institute for Systems Biology & Sage Bionetworks.
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Journal ArticleDOI
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
Henrik Sperber,Julie Mathieu,Yuliang Wang,Amy Ferreccio,Jennifer Hesson,Zhuojin Xu,Karin A. Fischer,Arikketh Devi,Arikketh Devi,Damien Detraux,Haiwei Gu,Stephanie L. Battle,Megan R. Showalter,Cristina Valensisi,Jason H. Bielas,Jason H. Bielas,Nolan G. Ericson,Lilyana Margaretha,Aaron M. Robitaille,Daciana Margineantu,Oliver Fiehn,Oliver Fiehn,David M. Hockenbery,C. Anthony Blau,Daniel Raftery,Daniel Raftery,Adam A. Margolin,R. David Hawkins,Randall T. Moon,Randall T. Moon,Carol B. Ware,Hannele Ruohola-Baker +31 more
TL;DR: It is shown that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs), supporting the hypothesis that the metabolome regulates the epigenetic landscape of the earliest steps in human development.
Journal ArticleDOI
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE.
TL;DR: The eicosanoid metabolic pathway is identified, especially reactions catalyzing the production of leukotrienes from arachidnoic acid, as potential drug targets that selectively affect tumor tissues.
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Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.
Clayton E. Friedman,Quan Nguyen,Samuel W. Lukowski,Abbigail Helfer,Han Sheng Chiu,Jason W. Miklas,Shiri Levy,Shengbao Suo,Jing-Dong J. Han,Pierre Osteil,Guangdun Peng,Naihe Jing,Naihe Jing,Greg J. Baillie,Anne Senabouth,Angelika N. Christ,Timothy J. C. Bruxner,Charles E. Murry,Emily S. W. Wong,Jun Ding,Yuliang Wang,James E. Hudson,Hannele Ruohola-Baker,Ziv Bar-Joseph,Patrick P.L. Tam,Patrick P.L. Tam,Joseph E. Powell,Joseph E. Powell,Nathan J. Palpant +28 more
TL;DR: It is found that hypertrophic signaling is not effectively activated during monolayer-based cardiac differentiation, thereby preventing expression of HOPX and its activation of downstream genes that govern late stages of cardiomyocyte maturation.
Journal ArticleDOI
Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells.
Xiulan Yang,Marita L. Rodriguez,Andrea Leonard,Lihua Sun,Karin A. Fischer,Yuliang Wang,Julia Ritterhoff,Limei Zhao,Stephen C. Kolwicz,Lil Pabon,Hans Reinecke,Nathan J. Sniadecki,Rong Tian,Hannele Ruohola-Baker,Haodong Xu,Charles E. Murry +15 more
TL;DR: Fatty acids increase human cardiomyocyte hypertrophy, force generation, calcium dynamics, action potential upstroke velocity, and oxidative capacity and should facilitate hPSC-CM usage for cell therapy, disease modeling, and drug/toxicity screens.
Journal ArticleDOI
Human Organ-Specific Endothelial Cell Heterogeneity.
Raluca Marcu,Yoon Jung Choi,Jun Xue,Chelsea L. Fortin,Yuliang Wang,Ryan J. Nagao,Jin Xu,James W. MacDonald,Theo K. Bammler,Charles E. Murry,Kimberly A. Muczynski,Kelly R. Stevens,Jonathan Himmelfarb,Stephen M. Schwartz,Ying Zheng +14 more
TL;DR: The link between human EC heterogeneity and organ development is shown and can be exploited therapeutically to contribute in organ regeneration, disease modeling, as well as guiding differentiation of tissue-specific ECs from human pluripotent stem cells.