D
Damien Detraux
Researcher at University of Washington
Publications - 10
Citations - 538
Damien Detraux is an academic researcher from University of Washington. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 7, co-authored 7 publications receiving 393 citations. Previous affiliations of Damien Detraux include Université de Namur.
Papers
More filters
Journal ArticleDOI
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
Henrik Sperber,Julie Mathieu,Yuliang Wang,Amy Ferreccio,Jennifer Hesson,Zhuojin Xu,Karin A. Fischer,Arikketh Devi,Arikketh Devi,Damien Detraux,Haiwei Gu,Stephanie L. Battle,Megan R. Showalter,Cristina Valensisi,Jason H. Bielas,Jason H. Bielas,Nolan G. Ericson,Lilyana Margaretha,Aaron M. Robitaille,Daciana Margineantu,Oliver Fiehn,Oliver Fiehn,David M. Hockenbery,C. Anthony Blau,Daniel Raftery,Daniel Raftery,Adam A. Margolin,R. David Hawkins,Randall T. Moon,Randall T. Moon,Carol B. Ware,Hannele Ruohola-Baker +31 more
TL;DR: It is shown that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs), supporting the hypothesis that the metabolome regulates the epigenetic landscape of the earliest steps in human development.
Journal ArticleDOI
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.
Jason W. Miklas,Elisa C. Clark,Shiri Levy,Damien Detraux,Andrea Leonard,Kevin M. Beussman,Megan R. Showalter,Alec S.T. Smith,Peter Hofsteen,Xiulan Yang,Jesse Macadangdang,Tuula Manninen,Daniel Raftery,Anup Madan,Anu Suomalainen,Deok Ho Kim,Charles E. Murry,Oliver Fiehn,Oliver Fiehn,Nathan J. Sniadecki,Yuliang Wang,Hannele Ruohola-Baker +21 more
TL;DR: It is shown that the MTP deficient pathology in human cardiomyocytes leads to an abnormal cardiolipin pattern and suggests that cardiolIPin affecting compounds may serve as a potential therapy.
Journal ArticleDOI
Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.
Julie Mathieu,Damien Detraux,Damien Detraux,Daniel A. Kuppers,Yuliang Wang,Christopher Cavanaugh,Sonia B. Sidhu,Shiri Levy,Aaron M. Robitaille,Amy Ferreccio,T. Bottorff,A. McAlister,Logeshwaran Somasundaram,Filippo Artoni,Stephanie L. Battle,R. D. Hawkins,Randall T. Moon,Carol B. Ware,Patrick J. Paddison,Patrick J. Paddison,Hannele Ruohola-Baker +20 more
TL;DR: It is shown that FLCN Knock-out hESCs maintain the naïve pluripotent state but cannot exit the state since the critical transcription factor TFE3 remains active in the nucleus.
Journal ArticleDOI
First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.
James D. Moody,Shiri Levy,Julie Mathieu,Yalan Xing,Woojin Kim,Woojin Kim,Cheng Dong,Wolfram Tempel,Aaron M. Robitaille,Luke T. Dang,Amy Ferreccio,Damien Detraux,Sonia B. Sidhu,Licheng Zhu,Licheng Zhu,Lauren Carter,Chao Xu,Chao Xu,Cristina Valensisi,Yuliang Wang,R. David Hawkins,Jinrong Min,Randall T. Moon,Randall T. Moon,Stuart H. Orkin,David Baker,David Baker,Hannele Ruohola-Baker +27 more
TL;DR: The computational design of proteins that bind to the EZH2 interaction site on EED with subnanomolar affinity in vitro and form tight and specific complexes with EED in living cells are described.
Journal ArticleDOI
Metabolism as an early predictor of DPSCs aging
Dannie Macrin,Ammar Alghadeer,Yan Ting Zhao,Jason W. Miklas,Abdiasis M. Hussein,Damien Detraux,Aaron M. Robitaille,Anup Madan,Randall T. Moon,Yuliang Wang,Arikketh Devi,Arikketh Devi,Julie Mathieu,Hannele Ruohola-Baker +13 more
TL;DR: Using metabolic flux analysis, this study identifies Barx1 as a DPSCs marker and dissects the first predictive metabolic signature for DPSCs aging, indicating a loss of stem cell characteristics and spontaneous initiation of terminal differentiation.