Yanfeng Xi

TL;DR: High activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC tumors indicates that therapies targeting these pathways might be particularly promising strategies for ESCC.

TL;DR: This work re-analyzed whole-genome sequencing data from 31 ESCCs using Meerkat algorithm to predict somatic SVs and Patchwork to determine copy-number changes and found deletions and translocations with NHEJ and alt-EJ signature as the dominant SV types, and 16% of deletions were complex deletions.

TL;DR: Wang et al. as discussed by the authors analyzed the whole genomic, epigenomic, transcriptomic, and proteomic data of 155 esophageal squamous cell carcinomas (ESCCs) and developed a classifier with 28 features to identify the IM subtype, which predicted anti-PD-1 therapy response with 85.7% sensitivity and 90% specificity.

TL;DR: An antagonistic interaction was observed between ADIPOQ polymorphisms and lipid levels in coal miners and it was shown that hypertension risk was high for the subjects with rs2241766 TG+GG or rs1501299 GG under the low lipid level but low for those under the high lipid level.