M
Minghui He
Researcher at Beijing Institute of Genomics
Publications - 22
Citations - 2998
Minghui He is an academic researcher from Beijing Institute of Genomics. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 12 publications receiving 2546 citations. Previous affiliations of Minghui He include Beijing Genomics Institute & South China University of Technology.
Papers
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Journal ArticleDOI
Identification of genomic alterations in oesophageal squamous cell cancer
Yongmei Song,Lin Li,Yunwei Ou,Zhibo Gao,En-Min Li,Xiangchun Li,Weimin Zhang,Jiaqian Wang,Li-Yan Xu,Yong Zhou,Xiao-Juan Ma,Lingyan Liu,Zitong Zhao,Xuanlin Huang,Jing Fan,Lijia Dong,Gang Chen,Liying Ma,Jie Yang,Chen Longyun,Minghui He,Li Miao,Xuehan Zhuang,Kai Huang,Kunlong Qiu,Guangliang Yin,Guangwu Guo,Qiang Feng,Peishan Chen,Zhi-Yong Wu,Jian-Yi Wu,Ling Ma,Jinyang Zhao,Longhai Luo,Ming Fu,Bainan Xu,Bo Chen,Yingrui Li,Tong Tong,Mingrong Wang,Zhihua Liu,Dongxin Lin,Xiuqing Zhang,Huanming Yang,Jun Wang,Qimin Zhan +45 more
TL;DR: Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking, and novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC are explored.
Journal ArticleDOI
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Yaoting Gui,Guangwu Guo,Yi Huang,Xueda Hu,Aifa Tang,Aifa Tang,Shengjie Gao,Renhua Wu,Chao Chen,Xianxin Li,Liang Zhou,Minghui He,Zesong Li,Zesong Li,Xiaojuan Sun,Wenlong Jia,Jinnong Chen,Shangming Yang,Fangjian Zhou,Xiaokun Zhao,Shengqing Wan,Rui Ye,Chaozhao Liang,Zhisheng Liu,Peide Huang,Chunxiao Liu,Hui Jiang,Yong Wang,Hancheng Zheng,Liang Sun,Xingwang Liu,Zhimao Jiang,Dafei Feng,Jing Chen,Song Wu,Jing Zou,Zhongfu Zhang,Ruilin Yang,Jun Zhao,Congjie Xu,Weihua Yin,Zhichen Guan,Jiongxian Ye,Hong Zhang,Jingxiang Li,Karsten Kristiansen,Michael L. Nickerson,Dan Theodorescu,Yingrui Li,Xiuqing Zhang,Songgang Li,Jian Wang,Huanming Yang,Jun Wang,Zhiming Cai,Zhiming Cai +55 more
TL;DR: The results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Journal ArticleDOI
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
Guangwu Guo,Yaoting Gui,Shengjie Gao,Aifa Tang,Aifa Tang,Xueda Hu,Yi Huang,Yi Huang,Wenlong Jia,Zesong Li,Zesong Li,Minghui He,Liang Sun,Pengfei Song,Xiaojuan Sun,Xiaokun Zhao,Sangming Yang,Chaozhao Liang,Shengqing Wan,Fangjian Zhou,Chao Chen,Jialou Zhu,Xianxin Li,Minghan Jian,Liang Zhou,Rui Ye,Peide Huang,Jing Chen,Tao Jiang,Xiao Liu,Yong Wang,Jing Zou,Zhimao Jiang,Renhua Wu,Song Wu,Fan Fan,Zhongfu Zhang,Lin Liu,Ruilin Yang,Xingwang Liu,Haibo Wu,Weihua Yin,Xia Zhao,Yuchen Liu,Huanhuan Peng,Bing-Hua Jiang,Qingxin Feng,Cailing Li,Jun Xie,Jingxiao Lu,Karsten Kristiansen,Yingrui Li,Xiuqing Zhang,Songgang Li,Jian Wang,Huanming Yang,Zhiming Cai,Zhiming Cai,Jun Wang +58 more
TL;DR: These findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network and detect frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP).
Journal ArticleDOI
Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma
Ling Zhang,Yong Zhou,Caixia Cheng,Heyang Cui,Le Cheng,Pengzhou Kong,Jiaqian Wang,Yin Li,Wenliang Chen,Bin Song,Fang Wang,Zhiwu Jia,Lin Li,Yaoping Li,Bin Yang,Jing Liu,Ruyi Shi,Yanghui Bi,Yanyan Zhang,Juan Wang,Zhenxiang Zhao,Xiaoling Hu,Jie Yang,Hongyi Li,Zhibo Gao,Gang Chen,Xuanlin Huang,Xukui Yang,Shengqing Wan,Chao Chen,Bin Li,Yongkai Tan,Chen Longyun,Minghui He,Sha Xie,Xiangchun Li,Xuehan Zhuang,Mengyao Wang,Zhi Xia,Longhai Luo,Jie Ma,Bing Dong,Jiuzhou Zhao,Yongmei Song,Yunwei Ou,Enming Li,Li-Yan Xu,Jinfen Wang,Yanfeng Xi,Guodong Li,Enwei Xu,Jianfang Liang,Xiaofeng Yang,Jiansheng Guo,Xing Chen,Yanbo Zhang,Qingshan Li,Lixin Liu,Yingrui Li,Xiuqing Zhang,Huanming Yang,Dongxin Lin,Xiaolong Cheng,Yongjun Guo,Jun Wang,Qimin Zhan,Yongping Cui +66 more
TL;DR: High activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC tumors indicates that therapies targeting these pathways might be particularly promising strategies for ESCC.
Journal ArticleDOI
SOAPfuse: an algorithm for identifying fusion transcripts from paired-end RNA-Seq data
Wenlong Jia,Kunlong Qiu,Minghui He,Pengfei Song,Quan Zhou,Feng Zhou,Yuan Yu,Dandan Zhu,Michael L. Nickerson,Shengqing Wan,Xiangke Liao,Xiaoqian Zhu,Shaoliang Peng,Yingrui Li,Jun Wang,Guangwu Guo +15 more
TL;DR: A new method to identify fusion transcripts from paired-end RNA-Seq data by applying an improved partial exhaustion algorithm to construct a library of fusion junction sequences, and employs a series of filters to nominate high-confidence fusion transcripts.