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Chen Longyun
Researcher at Beijing Genomics Institute
Publications - 14
Citations - 1424
Chen Longyun is an academic researcher from Beijing Genomics Institute. The author has contributed to research in topics: Mutation (genetic algorithm) & Mutation frequency. The author has an hindex of 7, co-authored 14 publications receiving 1165 citations. Previous affiliations of Chen Longyun include Beijing Institute of Genomics.
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Journal ArticleDOI
Identification of genomic alterations in oesophageal squamous cell cancer
Yongmei Song,Lin Li,Yunwei Ou,Zhibo Gao,En-Min Li,Xiangchun Li,Weimin Zhang,Jiaqian Wang,Li-Yan Xu,Yong Zhou,Xiao-Juan Ma,Lingyan Liu,Zitong Zhao,Xuanlin Huang,Jing Fan,Lijia Dong,Gang Chen,Liying Ma,Jie Yang,Chen Longyun,Minghui He,Li Miao,Xuehan Zhuang,Kai Huang,Kunlong Qiu,Guangliang Yin,Guangwu Guo,Qiang Feng,Peishan Chen,Zhi-Yong Wu,Jian-Yi Wu,Ling Ma,Jinyang Zhao,Longhai Luo,Ming Fu,Bainan Xu,Bo Chen,Yingrui Li,Tong Tong,Mingrong Wang,Zhihua Liu,Dongxin Lin,Xiuqing Zhang,Huanming Yang,Jun Wang,Qimin Zhan +45 more
TL;DR: Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking, and novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC are explored.
Journal ArticleDOI
Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma
Ling Zhang,Yong Zhou,Caixia Cheng,Heyang Cui,Le Cheng,Pengzhou Kong,Jiaqian Wang,Yin Li,Wenliang Chen,Bin Song,Fang Wang,Zhiwu Jia,Lin Li,Yaoping Li,Bin Yang,Jing Liu,Ruyi Shi,Yanghui Bi,Yanyan Zhang,Juan Wang,Zhenxiang Zhao,Xiaoling Hu,Jie Yang,Hongyi Li,Zhibo Gao,Gang Chen,Xuanlin Huang,Xukui Yang,Shengqing Wan,Chao Chen,Bin Li,Yongkai Tan,Chen Longyun,Minghui He,Sha Xie,Xiangchun Li,Xuehan Zhuang,Mengyao Wang,Zhi Xia,Longhai Luo,Jie Ma,Bing Dong,Jiuzhou Zhao,Yongmei Song,Yunwei Ou,Enming Li,Li-Yan Xu,Jinfen Wang,Yanfeng Xi,Guodong Li,Enwei Xu,Jianfang Liang,Xiaofeng Yang,Jiansheng Guo,Xing Chen,Yanbo Zhang,Qingshan Li,Lixin Liu,Yingrui Li,Xiuqing Zhang,Huanming Yang,Dongxin Lin,Xiaolong Cheng,Yongjun Guo,Jun Wang,Qimin Zhan,Yongping Cui +66 more
TL;DR: High activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC tumors indicates that therapies targeting these pathways might be particularly promising strategies for ESCC.
Journal ArticleDOI
Genomic heterogeneity of multiple synchronous lung cancer
Yu Liu,Jianjun Zhang,Lin Li,Guangliang Yin,Jianhua Zhang,Shan Zheng,Hannah Cheung,Ning Wu,Ning Lu,Xizeng Mao,L. Yang,Jiexin Zhang,Li Zhang,Sahil Seth,Huang Chen,Xingzhi Song,Kan Liu,Yong-qiang Xie,Lina Zhou,Chuanduo Zhao,Naijun Han,W Q Chen,Susu Zhang,Chen Longyun,Wenjun Cai,Miaozhong Shen,Ningzhi Xu,Shujun Cheng,Huanming Yang,J. Jack Lee,Arlene M. Correa,Junya Fujimoto,Carmen Behrens,Chi Wan Chow,William N. William,John V. Heymach,Waun Ki Hong,Stephen G. Swisher,Ignacio I. Wistuba,Jun Wang,Jun Wang,Dongmei Lin,Xiangyang Liu,P. Andrew Futreal,Yanning Gao +44 more
TL;DR: Analysis of genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC suggests different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.
Journal ArticleDOI
Distinct subtypes of gastric cancer defined by molecular characterization include novel mutational signatures with prognostic capability
Xiangchun Li,Xiangchun Li,William K.K. Wu,Rui Xing,Sunny H. Wong,Yuexin Liu,Xiaodong Fang,Yanlin Zhang,Mengyao Wang,Jiaqian Wang,Lin Li,Yong Zhou,Senwei Tang,Shaoliang Peng,Kunlong Qiu,Chen Longyun,Kexin Chen,Huanming Yang,Wei Zhang,Matthew T. V. Chan,Youyong Lu,Joseph J.Y. Sung,Jun Yu +22 more
TL;DR: This work integrated somatic mutational profiles and clinicopathologic information from 544 gastric cancer patients from previous genomic studies to identify significantly mutated genes (SMG) with prognostic relevance and a mutation signature predictive of patient survival in newly classified subtypes of Gastric cancer.
Journal ArticleDOI
Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma
Chenguang Li,Chenguang Li,Zhibo Gao,Fei Li,Xiangchun Li,Yihua Sun,Mengyun Wang,Dan Li,Rui Wang,Fuming Li,Rong Fang,Yunjian Pan,Xiaoyang Luo,Jing He,Liangtao Zheng,Jufeng Xia,Li-Xin Qiu,Jun He,Ting Ye,Ruoxin Zhang,Minghui He,Meiling Zhu,Haichuan Hu,Tingyan Shi,Xiaoyan Zhou,Menghong Sun,Shilin Tian,Yong Zhou,Qiaoxiu Wang,Chen Longyun,Guangliang Yin,Jingya Lu,Renhua Wu,Guangwu Guo,Yingrui Li,Xueda Hu,Lin Li,Asan,Qin Wang,Ye Yin,Qiang Feng,Bin Wang,Hang Wang,Mingbang Wang,Xiaonan Yang,Xiuqing Zhang,Huanming Yang,Li Jin,Cun Yu Wang,Hongbin Ji,Haiquan Chen,Jun Wang,Qingyi Wei,Qingyi Wei +53 more
TL;DR: It is observed that knockdown of CDH10 promoted cell proliferation, soft-agar colony formation, cell migration and cell invasion, and overexpression ofCDH10 inhibited cell proliferation.