F
Francois Bacot
Researcher at McGill University
Publications - 37
Citations - 7244
Francois Bacot is an academic researcher from McGill University. The author has contributed to research in topics: Genome-wide association study & Breast cancer. The author has an hindex of 26, co-authored 37 publications receiving 6321 citations. Previous affiliations of Francois Bacot include Vanderbilt University & Montreal Children's Hospital.
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Journal ArticleDOI
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Kyriaki Michailidou,Per Hall,Anna González-Neira,Maya Ghoussaini,Joe Dennis,Roger L. Milne,Marjanka K. Schmidt,Jenny Chang-Claude,Stig E. Bojesen,Manjeet K. Bolla,Qin Wang,Ed Dicks,Andy C. H. Lee,Clare Turnbull,Nazneen Rahman,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos Santos Silva,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Kamila Czene,Astrid K. Irwanto,Jianjun Liu,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Rebecca Hein,N. Dahmen,Lars Beckman,Alfons Meindl,Rita K. Schmutzler,Bertram Müller-Myhsok,Peter Lichtner,John L. Hopper,Melissa C. Southey,Enes Makalic,Daniel F. Schmidt,Andre G. Uitterlinden,Albert Hofman,David J. Hunter,Stephen J. Chanock,Daniel Vincent,Francois Bacot,Daniel C. Tessier,Sander Canisius,Lodewyk F. A. Wessels,Christopher A. Haiman,Mitul Shah,Robert Luben,Judith E. Brown,Craig Luccarini,Nils Schoof,Keith Humphreys,Jingmei Li,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Fergus J. Couch,Xianshu Wang,Celine M. Vachon,Kristen N. Stevens,Diether Lambrechts,Matthieu Moisse,Robert Paridaens,Marie Rose Christiaens,Anja Rudolph,Stefan Nickels,Dieter Flesch-Janys,Dieter Flesch-Janys,Dieter Flesch-Janys,Nichola Johnson,Zoe Aitken,Kirsimari Aaltonen,Kirsimari Aaltonen,Tuomas Heikkinen,Annegien Broeks,Laura J. Van 'T Veer,C. Ellen van der Schoot,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,M. Pilar Zamora,Jose Ignacio Arias Perez,Guillermo Pita,M. Rosario Alonso,Angela Cox,Ian W. Brock,Simon S. Cross,Malcolm W.R. Reed,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Annika Lindblom,Sara Margolin,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Agnes Jager,Quang M. Bui,Jennifer Stone,Gillian S. Dite,Carmel Apicella,Helen Tsimiklis,Graham G. Giles,Gianluca Severi,Laura Baglietto,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Michael Jones,Jonine D. Figueroa,Jolanta Lissowska,Louise A. Brinton,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Bernardo Bonanni,Peter Devilee,Rob A. E. M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Katarzyna Durda,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Vessela N. Kristensen,Hoda Anton-Culver,Susan L. Slager,Amanda E. Toland,Stephen Edge,Florentia Fostira,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Aiko Sueta,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Soo Hwang Teo,Cheng Har Yip,Sze Yee Phuah,Belinda K. Cornes,Mikael Hartman,Hui Miao,Wei-Yen Lim,J. H. Sng,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Shian Ling Ding,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,William Blot,Lisa B. Signorello,Qiuyin Cai,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Jacques Simard,M Garcia-Closas,Paul D.P. Pharoah,Georgia Chenevix-Trench,Alison M. Dunning,Javier Benitez,Douglas F. Easton +220 more
TL;DR: A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
Journal ArticleDOI
Association analysis identifies 65 new breast cancer risk loci
Kyriaki Michailidou,Kyriaki Michailidou,Sara Lindström,Sara Lindström,Joe Dennis,Jonathan Beesley,Shirley Hui,Siddhartha Kar,Audrey Lemaçon,Penny Soucy,Dylan M. Glubb,Asha Rostamianfar,Manjeet K. Bolla,Qin Wang,Jonathan Tyrer,Ed Dicks,Andy C. H. Lee,Zhaoming Wang,Jamie Allen,Renske Keeman,Ursula Eilber,Juliet D. French,Xiaoqing Chen,Laura Fachal,Karen McCue,Amy E. McCart Reed,Maya Ghoussaini,Jason S. Carroll,Xia Jiang,Hilary K. Finucane,Hilary K. Finucane,Marcia Adams,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Hoda Anton-Culver,Natalia Antonenkova,Volker Arndt,Kristan J. Aronson,Banu Arun,Paul L. Auer,Paul L. Auer,Francois Bacot,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Leslie Bernstein,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Paul Brennan,Hermann Brenner,Louise A. Brinton,Per Broberg,Ian W. Brock,Annegien Broeks,Angela Brooks-Wilson,Angela Brooks-Wilson,Sara Y. Brucker,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Katja Butterbach,Qiuyin Cai,Hui Cai,Trinidad Caldés,Federico Canzian,Angel Carracedo,Brian D. Carter,Jose E. Castelao,Tsun Leung Chan,Tongguang Cheng,Kee Seng Chia,Ji Yeob Choi,Hans Christiansen,Christine L. Clarke,Margriet Collée,Don M. Conroy,Emilie Cordina-Duverger,Sten Cornelissen,David G. Cox,David G. Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Lorraine Durcan,Miriam Dwek,Diana Eccles,Arif B. Ekici,A. Heather Eliassen,A. Heather Eliassen,Carolina Ellberg,Mingajeva Elvira,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Valerie Gaborieau,Marike Gabrielson,Manuela Gago-Dominguez,Yu Tang Gao,Susan M. Gapstur,José A. García-Sáenz,Mia M. Gaudet,Vassilios Georgoulias,Graham G. Giles,Graham G. Giles,Gord Glendon,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Grethe I. Grenaker Alnæs,Mervi Grip,Jacek Gronwald,Anne Grundy,Pascal Guénel,Lothar Haeberle,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,N Hamel,Susan E. Hankinson,Patricia Harrington,Steven N. Hart,Jaana M. Hartikainen,Mikael Hartman,Mikael Hartman,Alexander Hein,Jane Heyworth,Belynda Hicks,Peter Hillemanns,Dona N. Ho,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Ming-Feng Hou,Chia-Ni Hsiung,Guanmengqian Huang,Keith Humphreys,Junko Ishiguro,Hidemi Ito,Motoki Iwasaki,Hiroji Iwata,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Arja Jukkola-Vuorinen,Rudolf Kaaks,Maria Kabisch,Katarzyna Kaczmarek,Daehee Kang,Daehee Kang,Yoshio Kasuga,Michael J. Kerin,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Johanna I. Kiiski,Sung-Won Kim,Julia A. Knight,Julia A. Knight,Veli-Matti Kosma,Vessela N. Kristensen,Vessela N. Kristensen,Ute Krüger,Ava Kwong,Diether Lambrechts,Loic Le Marchand,Eunjung Lee,Min Hyuk Lee,Jong Won Lee,Chuen Neng Lee,Flavio Lejbkowicz,Jingmei Li,Jenna Lilyquist,Annika Lindblom,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jirong Long,Artitaya Lophatananon,Artitaya Lophatananon,Jan Lubinski,Craig Luccarini,Michael P. Lux,Edmond S. K. Ma,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Enes Makalic,Kathleen E. Malone,Ivana Maleva Kostovska,Arto Mannermaa,Siranoush Manoukian,JoAnn E. Manson,JoAnn E. Manson,Sara Margolin,Shivaani Mariapun,Maria Elena Martinez,Keitaro Matsuo,Dimitrios Mavroudis,James McKay,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Primitiva Menéndez,Usha Menon,J.-P. Meyer,Hui Miao,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Kenneth Muir,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Dong-Young Noh,Børge G. Nordestgaard,Børge G. Nordestgaard,Aaron D. Norman,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Curtis Olswold,Nick Orr,V. Shane Pankratz,Sue K. Park,Sue K. Park,Tjoung-Won Park-Simon,Rachel Lloyd,Jose Ignacio Arias Perez,Paolo Peterlongo,Julian Peto,Kelly-Anne Phillips,Mila Pinchev,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Darya Prokofyeva,Elizabeth W. Pugh,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gadi Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Jane Romm,Kathryn J. Ruddy,Thomas Rüdiger,Anja Rudolph,Matthias Ruebner,Emiel J. Th. Rutgers,Emmanouil Saloustros,Dale P. Sandler,Suleeporn Sangrajrang,Elinor J. Sawyer,Daniel F. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Fredrick R. Schumacher,Peter Schürmann,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Caroline Seynaeve,Mitul Shah,Priyanka Sharma,Chen-Yang Shen,Chen-Yang Shen,Grace Sheng,Mark E. Sherman,Martha J. Shrubsole,Xiao-Ou Shu,Ann Smeets,Christof Sohn,Melissa C. Southey,John J. Spinelli,John J. Spinelli,Christa Stegmaier,Sarah Stewart-Brown,Jennifer Stone,Jennifer Stone,Daniel O. Stram,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,Rulla M. Tamimi,Jack A. Taylor,Maria Tengström,Soo Hwang Teo,Mary Beth Terry,Daniel C. Tessier,Somchai Thanasitthichai,Kathrin Thöne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ling Tong,Diana Torres,Diana Torres,Thérèse Truong,Chiu-Chen Tseng,Shoichiro Tsugane,Hans-Ulrich Ulmer,Giske Ursin,Michael Untch,Celine M. Vachon,Christi J. van Asperen,David Van Den Berg,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Rob B. van der Luijt,Daniel Vincent,Jason Vollenweider,Quinten Waisfisz,Shan Wang-Gohrke,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Anna H. Wu,Lucy Xia,Taiki Yamaji,Xiaohong R. Yang,Cheng Har Yip,Keun-Young Yoo,Jyh-Cherng Yu,Wei Zheng,Ying Zheng,Bin Zhu,Argyrios Ziogas,Elad Ziv,Sunil R. Lakhani,Sunil R. Lakhani,Antonis C. Antoniou,Arnaud Droit,Irene L. Andrulis,Irene L. Andrulis,Christopher I. Amos,Fergus J. Couch,Paul D.P. Pharoah,Jenny Chang-Claude,Jenny Chang-Claude,Per Hall,David J. Hunter,Roger L. Milne,Roger L. Milne,Montserrat Garcia-Closas,Marjanka K. Schmidt,Stephen J. Chanock,Alison M. Dunning,Stacey L. Edwards,Gary D. Bader,Georgia Chenevix-Trench,Jacques Simard,Peter Kraft,Douglas F. Easton +396 more
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Journal ArticleDOI
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
Rosalind A. Eeles,Ali Amin Al Olama,Sara Benlloch,Edward J. Saunders,Daniel Leongamornlert,Malgorzata Tymrakiewicz,Maya Ghoussaini,Craig Luccarini,Joe Dennis,S Jugurnauth-Little,Tokhir Dadaev,David E. Neal,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,Kenneth Muir,Kenneth Muir,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Fredrik Wiklund,Henrik Grönberg,Christopher A. Haiman,Fredrick R. Schumacher,Brian E. Henderson,Loic Le Marchand,Sara Lindström,Peter Kraft,David J. Hunter,Susan M. Gapstur,Stephen J. Chanock,Sonja I. Berndt,Demetrius Albanes,Gerald L. Andriole,Johanna Schleutker,Maren Weischer,Federico Canzian,Elio Riboli,Timothy J. Key,Ruth C. Travis,Daniele Campa,Sue A. Ingles,Esther M. John,Esther M. John,Richard B. Hayes,Paul D.P. Pharoah,Nora Pashayan,Kay-Tee Khaw,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Lisa B. Signorello,Stephen N. Thibodeau,D J Schaid,Christiane Maier,Walther Vogel,Adam S. Kibel,Cezary Cybulski,Jan Lubinski,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Jong Y. Park,Radka Kaneva,Jyotsna Batra,Amanda B. Spurdle,Judith A. Clements,Manuel R. Teixeira,Manuel R. Teixeira,Ed Dicks,Andy C. H. Lee,Alison M. Dunning,Caroline Baynes,Don M. Conroy,Melanie Maranian,Shahana Ahmed,Koveela Govindasami,Michelle Guy,Rosemary A. Wilkinson,Emma J. Sawyer,Angela Morgan,David P. Dearnaley,Alan Horwich,Robert Huddart,Vincent Khoo,Chris Parker,Nicholas van As,C. R. J. Woodhouse,Alan Thompson,Tim Dudderidge,Chris Ogden,Colin Cooper,Artitaya Lophatananon,Angela Cox,Melissa C. Southey,John L. Hopper,Dallas R. English,Dallas R. English,Markus Aly,Jan Adolfsson,Jiangfeng Xu,Siqun L. Zheng,Meredith Yeager,Rudolf Kaaks,W. Ryan Diver,Mia M. Gaudet,Mariana C. Stern,Roman Corral,Amit Joshi,Ahva Shahabi,Tiina Wahlfors,Teuvo L.J. Tammela,Anssi Auvinen,Jarmo Virtamo,Peter Klarskov,Børge G. Nordestgaard,M. Andreas Røder,Sune F. Nielsen,Stig E. Bojesen,Stig E. Bojesen,Afshan Siddiq,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,William J. Blot,Wei Zheng,Qiuyin Cai,Shannon K. McDonnell,Antje E. Rinckleb,Bettina F. Drake,Graham A. Colditz,Dominika Wokołorczyk,Robert A. Stephenson,Robert A. Stephenson,Craig C. Teerlink,Heiko Müller,Dietrich Rothenbacher,Thomas A. Sellers,Hui-Yi Lin,C. Slavov,Vanio Mitev,Felicity Lose,Srilakshmi Srinivasan,Sofia Maia,Sofia Maia,Paula Paulo,Paula Paulo,Ethan M. Lange,Kathleen A. Cooney,Antonis C. Antoniou,Daniel Vincent,Francois Bacot,Daniel C. Tessier,Zsofia Kote-Jarai,Douglas F. Easton +156 more
TL;DR: In this paper, a custom Illumina array (iCOGS) was used to genotype 211,155 SNPs in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium.
Journal ArticleDOI
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Kyriaki Michailidou,Jonathan Beesley,Sara Lindström,Sander Canisius,Joe Dennis,Michael Lush,Mel Maranian,Manjeet K. Bolla,Qin Wang,Mitul Shah,Barbara Perkins,Kamila Czene,Mikael Eriksson,Hatef Darabi,Judith S. Brand,Stig E. Bojesen,Børge G. Nordestgaard,Henrik Flyger,Henrik Flyger,Sune F. Nielsen,Nazneen Rahman,Clare Turnbull,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos-Santos-Silva,Jenny Chang-Claude,Dieter Flesch-Janys,Anja Rudolph,Ursula Eilber,Sabine Behrens,Heli Nevanlinna,Taru A. Muranen,Taru A. Muranen,Kristiina Aittomäki,Kristiina Aittomäki,Carl Blomqvist,Carl Blomqvist,Sofia Khan,Sofia Khan,Kirsimari Aaltonen,Kirsimari Aaltonen,Habibul Ahsan,Muhammad G. Kibriya,Alice S. Whittemore,Esther M. John,Kathleen E. Malone,Marilie D. Gammon,Marilie D. Gammon,Regina M. Santella,Giske Ursin,Giske Ursin,Enes Makalic,Daniel F. Schmidt,Graham Casey,David J. Hunter,Susan M. Gapstur,Mia M. Gaudet,W. Ryan Diver,Christopher A. Haiman,Fredrick R. Schumacher,Brian E. Henderson,Loic Le Marchand,Christine D. Berg,Stephen J. Chanock,Jonine D. Figueroa,Robert N. Hoover,Diether Lambrechts,Patrick Neven,Patrick Neven,Hans Wildiers,Erik Van Limbergen,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Fergus J. Couch,Janet E. Olson,Emily Hallberg,Emily Hallberg,Emily Hallberg,Celine M. Vachon,Quinten Waisfisz,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Jingmei Li,Jianjun Liu,Jianjun Liu,Keith Humphreys,Keith Humphreys,Daehee Kang,Ji Yeob Choi,Sue K. Park,Keun-Young Yoo,Keun-Young Yoo,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Pascal Guénel,Thérèse Truong,Claire Mulot,Marie Sanchez,Barbara Burwinkel,Frederik Marme,Harald Surowy,Christof Sohn,Anna H. Wu,Chiu-Chen Tseng,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Anna González-Neira,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Xiao-Ou Shu,Xiao-Ou Shu,Wei Lu,Wei Lu,Wei Lu,Yu Tang Gao,Yu Tang Gao,Yu Tang Gao,Hui Cai,Hui Cai,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Irene L. Andrulis,Julia A. Knight,Julia A. Knight,Gord Glendon,Gord Glendon,Anna Marie Mulligan,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Annika Lindblom,Sara Margolin,Soo Hwang Teo,Cheng Har Yip,Nur Aishah Taib,Gie Hooi Tan,Maartje J. Hooning,Antoinette Hollestelle,John W. M. Martens,J. Margriet Collée,William Blot,Lisa B. Signorello,Qiuyin Cai,John L. Hopper,John L. Hopper,Melissa C. Southey,Helen Tsimiklis,Carmel Apicella,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Pei Ei Wu,Ming-Feng Hou,Vessela N. Kristensen,Silje Nord,Grethe I. Grenaker Alnæs,Graham G. Giles,Roger L. Milne,Catriona McLean,Catriona McLean,Federico Canzian,Federico Canzian,Dimitrios Trichopoulos,Petra P.H. Peeters,Eiliv Lund,Malin Sund,Kay-Tee Khaw,Marc J. Gunter,Domenico Palli,Lotte Maxild Mortensen,Laure Dossus,José María Huerta,José María Huerta,A. Meindl,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Sarah Stewart-Brown,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Pornthep Siriwanarangsan,Mikael Hartman,Hui Miao,Kee Seng Chia,Ching Wan Chan,Peter A. Fasching,Alexander Hein,Matthias W. Beckmann,Lothar Haeberle,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Anthony J. Swerdlow,Louise A. Brinton,Montserrat Garcia-Closas,Wei Zheng,Sandra L. Halverson,Martha J. Shrubsole,Martha J. Shrubsole,Jirong Long,Jirong Long,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Katri Pylkäs,Arja Jukkola-Vuorinen,Arja Jukkola-Vuorinen,Mervi Grip,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Loris Bernard,Natalia Bogdanova,Natalia Bogdanova,Thilo Dörk,Thilo Dörk,Arto Mannermaa,Arto Mannermaa,Vesa Kataja,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Tomasz Huzarski,Suleeporn Sangrajrang,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Susan L. Slager,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Maria Kabisch,Diana Torres,Susan L. Neuhausen,Hoda Anton-Culver,Craig Luccarini,Caroline Baynes,S. Ahmed,Catherine S. Healey,Daniel C. Tessier,Daniel Vincent,Francois Bacot,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Jacques Simard,Paul D.P. Pharoah,Peter Kraft,Alison M. Dunning,Georgia Chenevix-Trench,Per Hall,Douglas F. Easton +283 more
TL;DR: 15 new loci associated with breast cancer at P < 5 × 10−8 are identified, and one association appears to be driven by an amino acid substitution encoded in EXO1, which is found in women of European ancestry.
Journal ArticleDOI
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Nasim Mavaddat,Paul D.P. Pharoah,Kyriaki Michailidou,Jonathan Tyrer,Mark N. Brook,Mark N. Brook,Manjeet K. Bolla,Qin Wang,Joe Dennis,Alison M. Dunning,Mitul Shah,Robert Luben,Judith E. Brown,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Kamila Czene,Hatef Darabi,Mikael Eriksson,Julian Peto,Isabel dos-Santos-Silva,Frank Dudbridge,Nichola Johnson,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Emiel J. Th. Rutgers,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Jonine D. Figueroa,Stephen J. Chanock,Louise A. Brinton,Jolanta Lissowska,Fergus J. Couch,Janet E. Olson,Celine M. Vachon,Vernon S. Pankratz,Diether Lambrechts,Diether Lambrechts,Hans Wildiers,Chantal Van Ongeval,Erik Van Limbergen,Vessela N. Kristensen,Vessela N. Kristensen,Grethe I. Grenaker Alnæs,Silje Nord,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Peter A. Fasching,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Barbara Burwinkel,Barbara Burwinkel,Frederik Marme,Frederik Marme,Andreas Schneeweiss,Andreas Schneeweiss,Christof Sohn,Amy Trentham-Dietz,Polly A. Newcomb,Polly A. Newcomb,Linda Titus,Kathleen M. Egan,David J. Hunter,David J. Hunter,Sara Lindström,Sara Lindström,Rulla M. Tamimi,Peter Kraft,Peter Kraft,Nazneen Rahman,Clare Turnbull,Anthony Renwick,Sheila Seal,Sheila Seal,Jingmei Li,Jianjun Liu,Keith Humphreys,Javier Benitez,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Natalia Bogdanova,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Hoda Anton-Culver,Susan L. Neuhausen,Argyrios Ziogas,Leslie Bernstein,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Elza Khusnutdinova,Marina Bermisheva,Marina Bermisheva,Darya Prokofyeva,Zalina Takhirova,Alfons Meindl,Rita K. Schmutzler,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Rongxi Yang,Peter Schürmann,Michael Bremer,Hans Christiansen,Tjoung Won Park-Simon,Peter Hillemanns,Pascal Guénel,Pascal Guénel,Thérèse Truong,Thérèse Truong,Florence Menegaux,Florence Menegaux,Marie Sanchez,Marie Sanchez,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Valeria Pensotti,John L. Hopper,Helen Tsimiklis,Carmel Apicella,Melissa C. Southey,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Yon Ko,Yon Ko,Alice J. Sigurdson,Michele M. Doody,Ute Hamann,Diana Torres,Hans Ulrich Ulmer,Asta Försti,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Irene L. Andrulis,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Georgia Chenevix-Trench,Rosemary L. Balleine,Graham G. Giles,Roger L. Milne,Catriona McLean,Annika Lindblom,Sara Margolin,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Ursula Eilber,Shan Wang-Gohrke,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Linetta B. Koppert,Jane Carpenter,Christine L. Clarke,Rodney J. Scott,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Hermann Brenner,Volker Arndt,Christa Stegmaier,Aida Karina Dieffenbach,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Kenneth Offit,Kenneth Offit,Joseph Vijai,Joseph Vijai,Mark E. Robson,Rohini Rau-Murthy,Miriam Dwek,Miriam Dwek,Ruth Swann,Katherine Annie Perkins,Mark S. Goldberg,Mark S. Goldberg,Martine Dumont,Diana Eccles,William J. Tapper,Sajjad Rafiq,Esther M. John,Esther M. John,Alice S. Whittemore,Susan L. Slager,Drakoulis Yannoukakos,Amanda E. Toland,Song Yao,Wei Zheng,Sandra L. Halverson,Anna González-Neira,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Shahana Ahmed,Mel Maranian,Catherine S. Healey,Jacques Simard,Per Hall,Douglas F. Easton,Montserrat Garcia-Closas +242 more
TL;DR: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer, and the observed level of risk discrimination could inform targeted screening and prevention strategies.