Y
Yanping Zhu
Researcher at Newcastle University
Publications - 12
Citations - 1157
Yanping Zhu is an academic researcher from Newcastle University. The author has contributed to research in topics: Bacteroides thetaiotaomicron & Gene. The author has an hindex of 7, co-authored 9 publications receiving 887 citations. Previous affiliations of Yanping Zhu include University of Georgia & Technical University of Lisbon.
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Journal ArticleDOI
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Fiona Cuskin,Fiona Cuskin,Elisabeth C. Lowe,Max J. Temple,Yanping Zhu,Yanping Zhu,Elizabeth A. Cameron,Nicholas A. Pudlo,Nathan T. Porter,Karthik Urs,Andrew J. Thompson,Alan Cartmell,Artur Rogowski,Brian S. Hamilton,Rui Chen,Thomas J. Tolbert,Kathleen Piens,Debby Bracke,Wouter Vervecken,Z. Hakki,Gaetano Speciale,Jose L. Munōz-Munōz,Andrew T. Day,Maria J. Peña,Richard McLean,Michael D. L. Suits,Alisdair B. Boraston,Todd Atherly,Cherie J. Ziemer,Spencer J. Williams,Gideon J. Davies,D. Wade Abbott,D. Wade Abbott,Eric C. Martens,Harry J. Gilbert,Harry J. Gilbert +35 more
TL;DR: Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.
Journal ArticleDOI
Complex pectin metabolism by gut bacteria reveals novel catalytic functions
Didier Ndeh,Artur Rogowski,Artur Rogowski,Alan Cartmell,A.S. Luis,Arnaud Baslé,Joe Gray,Immacolata Venditto,Jonathon A. Briggs,Xiaoyang Zhang,Aurore Labourel,Nicolas Terrapon,Fanny Buffetto,Fanny Buffetto,Sergey A. Nepogodiev,Yao Xiao,Robert A. Field,Yanping Zhu,Malcolm A. O'Neill,Breeanna R. Urbanowicz,William S. York,Gideon J. Davies,D. Wade Abbott,Marie-Christine Ralet,Eric C. Martens,Bernard Henrissat,Bernard Henrissat,Bernard Henrissat,Harry J. Gilbert +28 more
TL;DR: It is shown that the gut bacterium Bacteroides thetaiotaomicron uses the most structurally complex glycan known: the plant pectic polysaccharide rhamnogalacturonan-II, cleaving all but 1 of its 21 distinct glycosidic linkages.
Journal ArticleDOI
Mechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiont
Yanping Zhu,Michael D. L. Suits,Andrew J. Thompson,Sambhaji Chavan,Zoran Dinev,Claire Dumon,Claire Dumon,Nicola Smith,Kelley W. Moremen,Yong Xiang,Aloysius Siriwardena,Spencer J. Williams,Harry J. Gilbert,Harry J. Gilbert,Gideon J. Davies +14 more
TL;DR: It is shown that GH92 mannosidases are alpha-mannosidases that act via a single displacement mechanism to utilize host N-glycans to exploit dietary polysaccharides and host glycans as nutrients.
Journal ArticleDOI
Structure and Function of an Arabinoxylan-specific Xylanase
Márcia A. S. Correia,Koushik Mazumder,Joana L. A. Brás,Susan J. Firbank,Yanping Zhu,Yanping Zhu,Richard J. Lewis,William S. York,Carlos M. G. A. Fontes,Harry J. Gilbert,Harry J. Gilbert +10 more
TL;DR: It is shown that a Clostridium thermocellum enzyme, designated CtXyl5A, hydrolyzes arabinoxylans but does not attack unsubstituted xylans, and in contrast to typical modular glycoside hydrolases, there is an extensive hydrophobic interface between CtGH5 and CtCBM6, and thus the two modules cannot function as independent entities.
Journal ArticleDOI
Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase.
Michael D. L. Suits,Yanping Zhu,Yanping Zhu,Edward J. Taylor,Julia Walton,David L. Zechel,Harry J. Gilbert,Harry J. Gilbert,Gideon J. Davies +8 more
TL;DR: It is shown that the Streptococcus pyogenes (M1 GAS SF370) GH38 enzyme (Spy1604; hereafter SpGH38) is an α−mannosidase with specificity for α−1,3 mannosidic linkages, and strongly hints at a function in the degradation of host N- or possibly O-glycans.