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Nathan T. Porter
Researcher at University of Michigan
Publications - 16
Citations - 1429
Nathan T. Porter is an academic researcher from University of Michigan. The author has contributed to research in topics: Bacteroides thetaiotaomicron & Bacteriophage. The author has an hindex of 11, co-authored 15 publications receiving 976 citations. Previous affiliations of Nathan T. Porter include Brigham Young University & Chalmers University of Technology.
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Journal ArticleDOI
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Fiona Cuskin,Fiona Cuskin,Elisabeth C. Lowe,Max J. Temple,Yanping Zhu,Yanping Zhu,Elizabeth A. Cameron,Nicholas A. Pudlo,Nathan T. Porter,Karthik Urs,Andrew J. Thompson,Alan Cartmell,Artur Rogowski,Brian S. Hamilton,Rui Chen,Thomas J. Tolbert,Kathleen Piens,Debby Bracke,Wouter Vervecken,Z. Hakki,Gaetano Speciale,Jose L. Munōz-Munōz,Andrew T. Day,Maria J. Peña,Richard McLean,Michael D. L. Suits,Alisdair B. Boraston,Todd Atherly,Cherie J. Ziemer,Spencer J. Williams,Gideon J. Davies,D. Wade Abbott,D. Wade Abbott,Eric C. Martens,Harry J. Gilbert,Harry J. Gilbert +35 more
TL;DR: Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.
Journal ArticleDOI
Expansion of bacteriophages is linked to aggravated intestinal inflammation and colitis
Lasha Gogokhia,Lasha Gogokhia,Kate Buhrke,Rickesha Bell,Brenden Hoffman,D. Garrett Brown,Christin Hanke-Gogokhia,Nadim J. Ajami,Matthew C. Wong,Arevik Ghazaryan,John F. Valentine,Nathan T. Porter,Eric C. Martens,Ryan M. O'Connell,Vinita Jacob,Ellen Scherl,Carl V. Crawford,W. Zac Stephens,Sherwood R. Casjens,Randy S. Longman,June L. Round +20 more
TL;DR: Results indicate that bacteriophages can alter mucosal immunity to impact mammalian health and reduce phages compared to non-responders.
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Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles.
Christina A. Hickey,Kristine A. Kuhn,David L. Donermeyer,Nathan T. Porter,Chunsheng Jin,Elizabeth A. Cameron,Haerin Jung,Gerard E. Kaiko,Marta Wegorzewska,Nicole P. Malvin,Robert W. P. Glowacki,Gunnar C. Hansson,Paul M. Allen,Eric C. Martens,Thaddeus S. Stappenbeck +14 more
TL;DR: It is demonstrated that bacterial OMVs and associated enzymes promote inflammatory immune stimulation in genetically susceptible hosts through access of B. theta OMVs to host immune cells was sulfatase dependent.
Journal ArticleDOI
The Critical Roles of Polysaccharides in Gut Microbial Ecology and Physiology
Nathan T. Porter,Eric C. Martens +1 more
TL;DR: This review considers multiple mechanisms through which polysaccharides mediate aspects of host-microbe symbiosis in the gut, including some affecting health, and highlights the potential to manipulate this system for health.
Journal ArticleDOI
Reciprocal Prioritization to Dietary Glycans by Gut Bacteria in a Competitive Environment Promotes Stable Coexistence.
TL;DR: The findings not only elucidate how B. ovatus and B. thetaiotaomicron strategically access glycans to maintain coexistence but also support the prioritization of carbohydrate utilization based on carbohydrate structure, advancing the understanding of the relationships between diet and the gut microbiome.