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Spencer J. Williams
Researcher at University of Melbourne
Publications - 248
Citations - 6409
Spencer J. Williams is an academic researcher from University of Melbourne. The author has contributed to research in topics: Glycoside hydrolase & Chemistry. The author has an hindex of 39, co-authored 233 publications receiving 5454 citations. Previous affiliations of Spencer J. Williams include University of California & University of British Columbia.
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Journal ArticleDOI
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Fiona Cuskin,Fiona Cuskin,Elisabeth C. Lowe,Max J. Temple,Yanping Zhu,Yanping Zhu,Elizabeth A. Cameron,Nicholas A. Pudlo,Nathan T. Porter,Karthik Urs,Andrew J. Thompson,Alan Cartmell,Artur Rogowski,Brian S. Hamilton,Rui Chen,Thomas J. Tolbert,Kathleen Piens,Debby Bracke,Wouter Vervecken,Z. Hakki,Gaetano Speciale,Jose L. Munōz-Munōz,Andrew T. Day,Maria J. Peña,Richard McLean,Michael D. L. Suits,Alisdair B. Boraston,Todd Atherly,Cherie J. Ziemer,Spencer J. Williams,Gideon J. Davies,D. Wade Abbott,D. Wade Abbott,Eric C. Martens,Harry J. Gilbert,Harry J. Gilbert +35 more
TL;DR: Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.
Journal ArticleDOI
Glycosyl fluorides in enzymatic reactions.
TL;DR: Synthetic applications in which glycosyl fluorides are used as gly cosyl donors in enzymatic transglycosylation reactions for the synthesis of oligo- and polysaccharides are covered, including the use of mutant glycosidases, which are able to catalyze the formation of glycosides without competing hydrolysis.
Journal ArticleDOI
'Click' cycloaddition catalysts: copper(I) and copper(II) tris(triazolylmethyl)amine complexes.
TL;DR: The CuI complex of the ' click' ligand tris(benzyltriazolylmethyl)amine is an unusual dinuclear dication with one triazole unit bridging two metal centers, and is an effective catalyst for the 'click' cycloaddition reaction.
Journal ArticleDOI
Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes
Wade Abbott,Orly Alber,Ed Bayer,Jean-Guy Berrin,Alisdair B. Boraston,Harry Brumer,Ryszard Brzezinski,Anthony J. Clarke,Beatrice Cobucci-Ponzano,Darrell Cockburn,Pedro M. Coutinho,Mirjam Czjzek,Bareket Dassa,Gideon J. Davies,Vincent G. H. Eijsink,Jens M. Eklöf,Alfons K. G. Felice,Elizabeth Ficko-Blean,Geoff Pincher,Thierry Fontaine,Zui Fujimoto,Kiyotaka Fujita,Shinya Fushinobu,Harry J. Gilbert,Tracey M. Gloster,Ethan D. Goddard-Borger,Ian R. Greig,Jan-Hendrik Hehemann,Glyn R. Hemsworth,Bernard Henrissat,Masafumi Hidaka,Ramon Hurtado-Guerrero,Kiyohiko Igarashi,Takuya Ishida,Štefan Janeček,Seino A. K. Jongkees,Nathalie Juge,Satoshi Kaneko,Takane Katayama,Motomitsu Kitaoka,Naotake Konno,Daniel Kracher,Anna A. Kulminskaya,Alicia Lammerts van Bueren,Sine Larsen,Junho Lee,Markus Linder,Leila LoLeggio,Roland Ludwig,Ana R. Luís,Mirko M. Maksimainen,Brian L. Mark,Richard McLean,Gurvan Michel,Cedric Montanier,Marco Moracci,Haruhide Mori,Hiroyuki Nakai,Wim Nerinckx,Takayuki Ohnuma,Richard W. Pickersgill,Kathleen Piens,Tirso Pons,Etienne Rebuffet,Peter J. Reilly,Magali Remaud-Simeon,Brian P. Rempel,Kyle Robinson,David R. Rose,Juha Rouvinen,Wataru Saburi,Yuichi Sakamoto,Mats Sandgren,Fathima Aidha Shaikh,Yuval Shoham,Franz J. St John,Jerry Ståhlberg,Michael D. L. Suits,Gerlind Sulzenbacher,Gerlind Sulzenbacher,Tomomi Sumida,Ryuichiro Suzuki,Birte Svensson,Toki Taira,Edward J. Taylor,Takashi Tonozuka,Breeanna R. Urbanowicz,Gustav Vaaje-Kolstad,Wim Van den Ende,Annabelle Varrot,Maxime Versluys,Florence Vincent,Florence Vincent,David J. Vocadlo,Warren W. Wakarchuk,Tom Wennekes,Rohan J. Williams,Spencer J. Williams,David Wilson,Stephen G. Withers,Katsuro Yaoi,Vivian L. Y. Yip,Ran Zhang +102 more
TL;DR: CAZypedia was initiated in 2007 to create a comprehensive, living encyclopedia of the carbohydrate-active enzymes (CAZymes) and associated carbohydrate-binding modules involved in the synthesis, modification and degradation of complex carbohydrates.
Journal ArticleDOI
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
TL;DR: Structural and kinetic data provide evidence that Asp-313 stabilizes the transition states flanking the oxazoline intermediate and also assists to correctly orient the 2-acetamido group for catalysis.