Y
Yaoyang Zhang
Researcher at Scripps Research Institute
Publications - 36
Citations - 2737
Yaoyang Zhang is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 24 publications receiving 2316 citations. Previous affiliations of Yaoyang Zhang include Max Planck Society.
Papers
More filters
Journal ArticleDOI
Protein Analysis by Shotgun/Bottom-up Proteomics
TL;DR: The progress of proteomics has been driven by the development of new technologies for peptide/protein separation, mass spectrometry analysis, isotope labeling for quantification, and bioinformatics data analysis.
Journal ArticleDOI
Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan,Nima Dolatabadi,Shing Fai Chan,Xiaofei Zhang,Mohd Waseem Akhtar,James C. Parker,Frank Soldner,Carmen R. Sunico,Saumya Nagar,Maria Talantova,Brian Lee,Kevin Lopez,Anthony Nutter,Bing Shan,Elena Molokanova,Yaoyang Zhang,Xuemei Han,Tomohiro Nakamura,Eliezer Masliah,John R. Yates,Nobuki Nakanishi,Aleksander Andreyev,Shu-ichi Okamoto,Rudolf Jaenisch,Rajesh Ambasudhan,Stuart A. Lipton,Stuart A. Lipton +26 more
TL;DR: In this article, a robust, patient-derived stem cell model of Parkinson's disease was used to identify mitochondrial toxin-induced perturbations in A53T α-synuclein (α-syn) mutant cells and isogenic mutation-corrected controls.
Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan,Nima Dolatabadi,Shing Fai Chan,Xiaofei Zhang,Mohd Waseem Akhtar,James C. Parker,Frank Soldner,Carmen R. Sunico,Saumya Nagar,Maria Talantova,Brian Lee,Kevin Lopez,Anthony Nutter,Bing Shan,Elena Molokanova,Yaoyang Zhang,Xuemei Han,Tomohiro Nakamura,Eliezer Masliah,John R. Yates,Nobuki Nakanishi,Aleksander Andreyev,Shu-ichi Okamoto,Rudolf Jaenisch,Rajesh Ambasudhan,Stuart A. Lipton,Stuart A. Lipton +26 more
TL;DR: Using a robust, patient-derived stem cell model of PD, the MEF2C-PGC1α pathway is identified as a therapeutic target to combat PD and mechanistic insight into gene-environmental interaction (GxE) in the pathogenesis of PD is provided.
Journal ArticleDOI
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
Justin R. Hassler,Donalyn L. Scheuner,Shiyu Wang,Jaeseok Han,Vamsi K. Kodali,Philip Li,Julie Nguyen,Jenny S. George,Cory Davis,Shengyang P. Wu,Yongsheng Bai,Maureen A. Sartor,James D. Cavalcoli,Harmeet Malhi,Gregory Baudouin,Yaoyang Zhang,John R. Yates,Pamela Itkin-Ansari,Niels Volkmann,Randal J. Kaufman +19 more
TL;DR: It is demonstrated that glucose activates IRE1α-mediated Xbp1 splicing to expand the secretory capacity of the β cell for increased proinsulin synthesis and to limit oxidative stress that leads to β cell failure.
Journal ArticleDOI
Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways.
Michaela D. Filiou,Yaoyang Zhang,Larysa Teplytska,Stefan Reckow,Philipp Gormanns,Giuseppina Maccarrone,Elisabeth Frank,Melanie S. Kessler,Boris Hambsch,Markus Nussbaumer,Mirjam Bunck,Tonia Ludwig,Alexander Yassouridis,Florian Holsboer,Rainer Landgraf,Christoph W. Turck +15 more
TL;DR: The data reveal alterations in energy metabolism, mitochondrial import and transport, oxidative stress, and neurotransmission, implicating a previously nonhighlighted role of mitochondria in modulating anxiety-related behavior.