S
Shiyu Wang
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 9
Citations - 2688
Shiyu Wang is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 8, co-authored 8 publications receiving 2277 citations. Previous affiliations of Shiyu Wang include Discovery Institute.
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Journal ArticleDOI
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Jaeseok Han,Sung Hoon Back,Junguk Hur,Yu Hsuan Lin,Robert D. Gildersleeve,Jixiu Shan,Celvie L. Yuan,Dawid Krokowski,Shiyu Wang,Maria Hatzoglou,Michael S. Kilberg,Maureen A. Sartor,Randal J. Kaufman +12 more
TL;DR: It is shown that eIF2α-phosphorylation-attenuated protein synthesis, and not Atf4 mRNA translation, promotes cell survival, and suggesting that limiting protein synthesis will be therapeutic for diseases caused by protein misfolding in the ER.
Journal ArticleDOI
The impact of the unfolded protein response on human disease
Shiyu Wang,Randal J. Kaufman +1 more
TL;DR: The unfolded protein response is an essential adaptive intracellular signaling pathway that responds to metabolic, oxidative stress, and inflammatory response pathways and is implicated in a variety of diseases including metabolic disease, neurodegenerative disease, inflammatory disease, and cancer.
Journal ArticleDOI
IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis
Shiyu Wang,Zhouji Chen,Vivian Lam,Jaeseok Han,Jaeseok Han,Justin R. Hassler,Justin R. Hassler,Brian N. Finck,Nicholas O. Davidson,Randal J. Kaufman,Randal J. Kaufman +10 more
TL;DR: A key role is identified for the inositol-requiring transmembrane kinase/endoribonuclease 1α-X box binding protein 1 (XBP1) arm of the UPR in regulation of hepatic very low-density lipoprotein (VLDL) assembly and secretion and may provide a therapeutic target for disorders of lipid metabolism.
Journal ArticleDOI
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
Justin R. Hassler,Donalyn L. Scheuner,Shiyu Wang,Jaeseok Han,Vamsi K. Kodali,Philip Li,Julie Nguyen,Jenny S. George,Cory Davis,Shengyang P. Wu,Yongsheng Bai,Maureen A. Sartor,James D. Cavalcoli,Harmeet Malhi,Gregory Baudouin,Yaoyang Zhang,John R. Yates,Pamela Itkin-Ansari,Niels Volkmann,Randal J. Kaufman +19 more
TL;DR: It is demonstrated that glucose activates IRE1α-mediated Xbp1 splicing to expand the secretory capacity of the β cell for increased proinsulin synthesis and to limit oxidative stress that leads to β cell failure.
Journal ArticleDOI
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis
Joseph C. Genereux,Song Qu,Minghai Zhou,Lisa M. Ryno,Shiyu Wang,Matthew D. Shoulders,Randal J. Kaufman,Corinne Ida Lasmézas,Jeffery W. Kelly,R. Luke Wiseman +9 more
TL;DR: ERdj3 is, to the authors' knowledge, the first metazoan chaperone whose secretion into the extracellular space is regulated by the UPR, revealing a new mechanism by which UPR activation regulatesextracellular proteostasis.