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Yasuhiro Watanabe
Researcher at Tottori University
Publications - 90
Citations - 1623
Yasuhiro Watanabe is an academic researcher from Tottori University. The author has contributed to research in topics: SOD1 & Internal medicine. The author has an hindex of 20, co-authored 84 publications receiving 1472 citations.
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Journal ArticleDOI
Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial
Masahisa Katsuno,Haruhiko Banno,Keisuke Suzuki,Yu Takeuchi,Motoshi Kawashima,Ichiro Yabe,Hidenao Sasaki,Masashi Aoki,Mitsuya Morita,Imaharu Nakano,Kazuaki Kanai,Shoichi Ito,Kinya Ishikawa,Hidehiro Mizusawa,Tomotaka Yamamoto,Shoji Tsuji,Kazuko Hasegawa,Takayoshi Shimohata,Masatoyo Nishizawa,Hiroaki Miyajima,Fumio Kanda,Yasuhiro Watanabe,Kenji Nakashima,Akira Tsujino,Taro Yamashita,Makoto Uchino,Yasushi Fujimoto,Fumiaki Tanaka,Gen Sobue +28 more
TL;DR: 48 weeks of treatment with leuprorelin did not show significant effects on swallowing function in patients with spinal and bulbar muscular atrophy, although it was well tolerated and further clinical trials with sensitive outcome measures should be done in subpopulations of patients.
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Familial amyotrophic lateral sclerosis with a two base pair deletion in superoxide dismutase 1: gene multisystem degeneration with intracytoplasmic hyaline inclusions in astrocytes.
Shinsuke Kato,Masaru Shimoda,Yasuhiro Watanabe,Kenji Nakashima,Kazuro Takahashi,Eisaku Ohama +5 more
TL;DR: The findings suggest that FALS due to an SOD1 gene mutation is potentially a multisystem degenerative disorder, affecting not only neurons, but also astrocytes.
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Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells
TL;DR: Results suggest that PI 3-kinase plays a role in adipocytic differentiation of 3T3-L1 cells.
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NPC1 gene mutations in Japanese patients with Niemann-Pick disease type C.
Toshiyuki Yamamoto,Eiji Nanba,Haruaki Ninomiya,Katsumi Higaki,Miyako Taniguchi,Haidi Zhang,Shinjiro Akaboshi,Yasuhiro Watanabe,Takao Takeshima,Koji Inui,Shintaro Okada,Akemi Tanaka,Norio Sakuragawa,Gilles Millat,Marie T. Vanier,Jill A. Morris,Peter G. Pentchev,Kousaku Ohno +17 more
TL;DR: Of the 14 mutations, the G1553A substitution that caused a splicing error of exon 9 appeared to be relatively common in Japanese patients, because two patients were homozygous and one patient was compound heterozygous for this mutation.
Journal ArticleDOI
Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1.
Yasuyo Fukada,Kenichi Yasui,Michio Kitayama,Koji Doi,Toshiya Nakano,Yasuhiro Watanabe,Kenji Nakashima +6 more
TL;DR: Gen expression in the spinal cord of SOD1(L126delTT) TgM by cDNA microarray is analyzed and four genes may be related to the pathogenesis of FALS, especially with regard to the progression of reactive astrocytes and the inflammatory response of microglial cells.