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Yasushi Shintani
Researcher at Takeda Pharmaceutical Company
Publications - 94
Citations - 5641
Yasushi Shintani is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Receptor & Peptide sequence. The author has an hindex of 25, co-authored 94 publications receiving 5266 citations. Previous affiliations of Yasushi Shintani include Japanese Ministry of International Trade and Industry.
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Journal ArticleDOI
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
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A G Protein-coupled Receptor Responsive to Bile Acids
Yuji Kawamata,Ryo Fujii,Masaki Hosoya,Masataka Harada,Hiromi Yoshida,Masanori Miwa,Shoji Fukusumi,Yugo Habata,Takashi Itoh,Yasushi Shintani,Shuji Hinuma,Yukio Fujisawa,Masahiko Fujino +12 more
TL;DR: It is found that a novel G protein-coupled receptor, TGR5, is responsive to bile acids as a cell-surface receptor, and was abundantly expressed in monocytes/macrophages in human and rabbit.
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New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
Shuji Hinuma,Yasushi Shintani,Shoji Fukusumi,Norio Iijima,Yoshio Matsumoto,Masaki Hosoya,Ryo Fujii,Takuya Watanabe,Kuniko Kikuchi,Yasuko Terao,Takahiko Yano,Takanori Yamamoto,Yuji Kawamata,Yugo Habata,Mari Asada,Chieko Kitada,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masaki Tanaka,Yasuhiko Ibata,Masahiko Fujino +21 more
TL;DR: In this paper, the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3, has been reported.
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Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors
Yasushi Masuda,Yoshihiro Takatsu,Yasuko Terao,Satoshi Kumano,Yoshihiro Ishibashi,Masato Suenaga,Michiko Abe,Shoji Fukusumi,Takuya Watanabe,Yasushi Shintani,Takao Yamada,Shuji Hinuma,Nobuhiro Inatomi,Tetsuya Ohtaki,Haruo Onda,Masahiko Fujino +15 more
TL;DR: The identification of the receptors for EG-VEGF/prokineticins may provide a novel molecular basis for the regulation of angiogenesis in endocrine glands.
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Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14).
Masaaki Mori,Tsukasa Sugo,Michiko Abe,Yukio Shimomura,Mika Kurihara,Chieko Kitada,Kuniko Kikuchi,Yasushi Shintani,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +11 more
TL;DR: Two molecular species of urotensin II (UII) were isolated from porcine spinal cords and identified as the endogenous ligands of a G-protein-coupled orphan receptor, SENR (sensory epithelium neuropeptide-like receptor), which is identical to GPR14.