Y
Yasutsugu Suzuki
Researcher at Pasteur Institute
Publications - 24
Citations - 803
Yasutsugu Suzuki is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 12, co-authored 22 publications receiving 575 citations. Previous affiliations of Yasutsugu Suzuki include Centre national de la recherche scientifique & Pennsylvania State University.
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Journal ArticleDOI
Native microbiome impedes vertical transmission of Wolbachia in Anopheles mosquitoes.
Grant L. Hughes,Brittany L. Dodson,Rebecca M. Johnson,Courtney C. Murdock,Hitoshi Tsujimoto,Hitoshi Tsujimoto,Yasutsugu Suzuki,Alyssa A. Patt,Long Cui,Carlos W. Nossa,Rhiannon Barry,Joyce M. Sakamoto,Emily A. Hornett,Jason L. Rasgon +13 more
TL;DR: The native microbiota of Anopheles impede vertical transmission of Wolbachia, and the bacterium Asaia was significantly reduced by antibiotic treatment in both mosquito species, suggesting that microbial interactions profoundly affect the host, and that microbiome incompatibility may influence distribution of Wolachia in arthropods.
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Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing
Duverney Chaverra-Rodriguez,Vanessa M. Macias,Grant L. Hughes,Grant L. Hughes,Sujit Pujhari,Yasutsugu Suzuki,Yasutsugu Suzuki,David R. Peterson,Donghun Kim,Sage McKeand,Jason L. Rasgon +10 more
TL;DR: A peptide (P2C) is identified that mediates transduction of Cas9 RNP from the female hemolymph to the developing mosquito oocytes, resulting in heritable gene editing of the offspring with efficiency as high as 0.3 mutants per injected mosquito.
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Uncovering the Repertoire of Endogenous Flaviviral Elements in Aedes Mosquito Genomes
Yasutsugu Suzuki,Lionel Frangeul,Laura B. Dickson,Hervé Blanc,Yann Verdier,Joëlle Vinh,Louis Lambrechts,Maria-Carla Saleh +7 more
TL;DR: The existence in vivo of flaviviral EVEs previously identified in mosquito cell lines are shown, and it is shown that EVEs have evolved differently in each mosquito population, suggesting a function at the RNA level.
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Non-retroviral Endogenous Viral Element Limits Cognate Virus Replication in Aedes aegypti Ovaries.
Yasutsugu Suzuki,Artem Baidaliuk,Artem Baidaliuk,Pascal Miesen,Pascal Miesen,Lionel Frangeul,Anna B. Crist,Sarah H. Merkling,Albin Fontaine,Sebastian Lequime,Isabelle Moltini-Conclois,Hervé Blanc,Ronald P. van Rij,Louis Lambrechts,Maria-Carla Saleh +14 more
TL;DR: Evidence is provided that antiviral piRNAs are produced in the presence of a naturally occurring EVE and its cognate virus, demonstrating a functional link between non-retroviral EVEs and antiviral immunity in a natural insect-virus interaction.
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Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects
Juan A Mondotte,Valérie Gausson,Lionel Frangeul,Yasutsugu Suzuki,Marie Vazeille,Vanesa Mongelli,Hervé Blanc,Anna-Bella Failloux,Maria-Carla Saleh +8 more
TL;DR: It is shown that Drosophila melanogaster and Aedes aegypti transmit antiviral immunological memory to their progeny that lasts throughout generations, broadly increasing the understanding of the immune response, host genome plasticity, and antiviral memory of the germline.