Y
Ye Tian
Researcher at Chinese Academy of Sciences
Publications - 25
Citations - 2583
Ye Tian is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 13 publications receiving 1899 citations. Previous affiliations of Ye Tian include University of California, Berkeley.
Papers
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Journal ArticleDOI
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Ryan C. Russell,Ye Tian,Hai-Xin Yuan,Hyun Woo Park,Yu Yun Chang,Joungmok Kim,Joungmok Kim,Haerin Kim,Thomas P. Neufeld,Andrew Dillin,Kun-Liang Guan +10 more
TL;DR: A molecular mechanism linking ULK to the pro-autophagic lipid kinase VPS34 is described, whereby the activated ULK1 phosphorylates Beclin-1 on Ser 14, thereby enhancing the activity of the ATG14L-containing V PS34 complexes.
Journal ArticleDOI
C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms
Ye Tian,Zhipeng Li,Wanqiu Hu,Haiyan Ren,E Tian,Yu Zhao,Qun Lu,Xinxin Huang,Peiguo Yang,Xin Li,Xiaochen Wang,Attila L. Kovács,Li Yu,Hong Zhang +13 more
TL;DR: This study establishes C. elegans as a multicellular genetic model to delineate the autophagy pathway and provides mechanistic insights into the metazoan-specific autophagic process.
Journal ArticleDOI
Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt).
Ye Tian,Gilberto Garcia,Qian Bian,Kristan K. Steffen,Larry Joe,Suzanne Wolff,Barbara J Meyer,Andrew Dillin +7 more
TL;DR: A metabolic stress response is established and propagated into adulthood of animals through specific epigenetic modifications that allow for selective gene expression and lifespan extension.
Journal ArticleDOI
Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis
Kristen Berendzen,Jenni Durieux,Li-Wa Shao,Ye Tian,Hyun Eui Kim,Suzanne Wolff,Ying Liu,Andrew Dillin +7 more
TL;DR: It is found that an aggregation-prone protein expressed in the neurons of C. elegans binds to mitochondria, eliciting a global induction of a mitochondrial-specific unfolded protein response (UPR(mt), affecting whole-animal physiology.
Journal ArticleDOI
The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.
TL;DR: Neuronal expression of the Wnt ligand/EGL-20 is sufficient to induce cell-non-autonomous UPRmt in a retromer complex-, Wnt signaling-, and serotonin-dependent manner, clearly implicating Wnt signaled as a strong candidate for the "mitokine" signal.