Y
Ye Zhang
Researcher at University of California, Los Angeles
Publications - 29
Citations - 9502
Ye Zhang is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Astrocyte & Biology. The author has an hindex of 15, co-authored 24 publications receiving 7341 citations. Previous affiliations of Ye Zhang include Semel Institute for Neuroscience and Human Behavior & Stanford University.
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Journal ArticleDOI
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Ye Zhang,Kenian Chen,Steven A. Sloan,Mariko L. Bennett,Anja R. Scholze,Sean O'Keeffe,Hemali Phatnani,Paolo Guarnieri,Christine Caneda,Nadine Ruderisch,Shuyun Deng,Shane A. Liddelow,Chaolin Zhang,Richard Daneman,Tom Maniatis,Ben A. Barres,Jian Qian Wu +16 more
TL;DR: The authors' data provide clues as to how neurons and astrocytes differ in their ability to dynamically regulate glycolytic flux and lactate generation attributable to unique splicing of PKM2, the gene encoding the glycoleytic enzyme pyruvate kinase.
Journal ArticleDOI
Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.
Ye Zhang,Steven A. Sloan,Laura E. Clarke,Christine Caneda,Colton A. Plaza,Paul D. Blumenthal,Hannes Vogel,Gary K. Steinberg,Michael S. B. Edwards,Gordon Li,John A. Duncan,Samuel H. Cheshier,Lawrence M. Shuer,Edward F. Chang,Gerald A. Grant,Melanie Hayden Gephart,Ben A. Barres +16 more
TL;DR: The development of an immunopanning method to acutely purify astrocytes from fetal, juvenile, and adult human brains and to maintain these cells in serum-free cultures is reported, finding that human astroCytes have abilities similar to those of murine astroicytes in promoting neuronal survival, inducing functional synapse formation, and engulfing synaptosomes.
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A survey of human brain transcriptome diversity at the single cell level
Spyros Darmanis,Steven A. Sloan,Ye Zhang,Martin Enge,Christine Caneda,Lawrence M. Shuer,Melanie Hayden Gephart,Ben A. Barres,Stephen R. Quake +8 more
TL;DR: The first, to the authors' knowledge, single cell whole transcriptome analysis of human adult cortical samples is described, establishing an experimental and analytical framework with which the complexity of the human brain can be dissected on the single cell level.
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Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma.
Spyros Darmanis,Steven A. Sloan,Derek Croote,Marco Mignardi,Sophia B. Chernikova,Peyman Samghababi,Ye Zhang,Norma F. Neff,Mark Kowarsky,Christine Caneda,Gordon Li,Steven D. Chang,Ian D. Connolly,Yingmei Li,Ben A. Barres,Melanie Hayden Gephart,Stephen R. Quake +16 more
TL;DR: Despite the existence of significant heterogeneity among neoplastic cells, it is found that infiltrating GBM cells share a consistent gene signature between patients, suggesting a common mechanism of infiltration.
Journal ArticleDOI
Astrocyte heterogeneity: an underappreciated topic in neurobiology.
Ye Zhang,Ben A. Barres +1 more
TL;DR: Evidence has accumulated that suggests heterogeneity of astrocytes across brain regions as well as within the same brain regions, which will greatly aid investigation of the function of astracytes in normal brain aswell as the roles of astrospecies in neurological disorders.