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Yi-xin Qian
Researcher at Amgen
Publications - 9
Citations - 6621
Yi-xin Qian is an academic researcher from Amgen. The author has contributed to research in topics: Osteoclast & Chemistry. The author has an hindex of 7, co-authored 7 publications receiving 6421 citations.
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Journal ArticleDOI
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
TL;DR: The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.
Journal ArticleDOI
The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts
Teresa L. Burgess,Yi-xin Qian,Stephen Kaufman,Brian D. Ring,Gwyneth Van,C. Capparelli,Michael J. Kelley,Hailing Hsu,William J. Boyle,Colin R. Dunstan,Sylvia Hu,David L. Lacey +11 more
TL;DR: Findings indicate that, in addition to their effects on OC precursors, OPGL and OPG have profound and direct effects on mature OCs and indicate that the OC receptor, RANK, mediates OPGl's effects.
Journal ArticleDOI
The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism.
Teresa L. Burgess,E F Fisher,S L Ross,J V Bready,Yi-xin Qian,L A Bayewitch,A M Cohen,C J Herrera,Sylvia Hu,T B Kramer +9 more
TL;DR: The results suggest that previous AS data obtained using these and similar, contiguous guanosine-containing AS sequences be reevaluated and that there may be an additional class of nucleic acid compounds that have potential as antirestenosis therapeutics.
Journal ArticleDOI
Osteoclast markers accumulate on cells developing from human peripheral blood mononuclear precursors.
Judy Faust,Dave Lacey,Pamela Hunt,Teresa L. Burgess,Sheila Scully,Gwyneth Van,Alana Eli,Yi-xin Qian,Victoria Shalhoub +8 more
TL;DR: It is reported that cells expressing osteoclast markers differentiate from precursors present in nonmobilized peripheral blood mononuclear cells (PBMC), without the addition of stromal cells, growth factors, cytokines or steroids; and characterize their phenotype.
Journal ArticleDOI
Biosynthetic processing of neu differentiation factor. Glycosylation trafficking, and regulated cleavage from the cell surface.
TL;DR: In this article, the authors characterized the biosynthetic processing of different NDF isoforms in stably transfected Chinese hamster ovary cells and in the native cell line Rat 1-EJ.