Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
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TLDR
The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.About:
This article is published in Cell.The article was published on 1998-04-17 and is currently open access. It has received 5334 citations till now. The article focuses on the topics: Osteoclast maturation & Osteoclast fusion.read more
Citations
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Journal ArticleDOI
Osteoclast differentiation and activation
TL;DR: Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoporosis and activation of bone resorption, and how hormonal signals impact bone structure and mass.
Journal ArticleDOI
Bone Resorption by Osteoclasts
TL;DR: Osteopetrotic mutants have provided a wealth of information about the genes that regulate the differentiation of osteoclasts and their capacity to resorb bone.
Journal ArticleDOI
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Journal ArticleDOI
Signalling pathways of the TNF superfamily: a double-edged sword.
TL;DR: Two different tumour-necrosis factors, first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice, and blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases.
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Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
TL;DR: The role and the molecular mechanism of action of regulatory molecules, such as cytokines and hormones, in osteoclast and osteoblast birth and apoptosis are reviewed to review the evidence for the contribution of changes in bone cell birth or death to the pathogenesis of the most common forms of osteoporosis.
References
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Journal ArticleDOI
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
William S. Simonet,David L. Lacey,Colin R. Dunstan,Michael J. Kelley,Ming-Shi Chang,R Lüthy,Hung Q. Nguyen,S Wooden,L Bennett,Tom Boone,Grant Shimamoto,Margaret L. DeRose,Robin Elliott,Anne Colombero,Hong-Lin Tan,Geraldine Trail,John K. Sullivan,E. Davy,N. Bucay,L Renshaw-Gegg,T.M Hughes,Dave Hill,W Pattison,Patricia Shehan Campbell,S Sander,Gwyneth Van,John E. Tarpley,P Derby,Richard Lee,William J. Boyle +29 more
TL;DR: Data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.
Journal ArticleDOI
Identification and characterization of a new member of the TNF family that induces apoptosis
Steven R. Wiley,Ken Schooley,Pamela J. Smolak,Wenie S. Din,Chang-Pin Huang,Jillian Nicholl,Grant R. Sutherland,Terri Davis Smith,Charles Rauch,Craig A. Smith,Raymond G. Goodwin +10 more
TL;DR: A novel tumor necrosis factor (TNF) family member has been cloned and characterized, and the TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members.
Journal ArticleDOI
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
Dirk M. Anderson,Eugene Maraskovsky,William L. Billingsley,William C. Dougall,Mark E. Tometsko,Eileen R. Roux,Mark Teepe,Robert F. DuBose,David Cosman,Laurent J. Galibert +9 more
TL;DR: RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells.
Journal ArticleDOI
Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family *
Robert M. Pitti,Scot A. Marsters,Siegfried Ruppert,Christopher J. Donahue,Alison Moore,Avi Ashkenazi +5 more
TL;DR: Results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.
Journal ArticleDOI
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
David Banner,Allan D'Arcy,Wolfgang Janes,Reiner L. Gentz,Hans-Joachim Schoenfeld,Clemens Broger,Hansruedi Loetscher,Werner Lesslauer +7 more
TL;DR: The X-ray crystal structure of the complex of the extracellular domain of the human 55 kd tumor necrosis factor (TNF) receptor with human TNF beta has been determined and is likely to be representative of the nerve growth factor (NGF)/TNF receptor family as a whole.
Related Papers (5)
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
William S. Simonet,David L. Lacey,Colin R. Dunstan,Michael J. Kelley,Ming-Shi Chang,R Lüthy,Hung Q. Nguyen,S Wooden,L Bennett,Tom Boone,Grant Shimamoto,Margaret L. DeRose,Robin Elliott,Anne Colombero,Hong-Lin Tan,Geraldine Trail,John K. Sullivan,E. Davy,N. Bucay,L Renshaw-Gegg,T.M Hughes,Dave Hill,W Pattison,Patricia Shehan Campbell,S Sander,Gwyneth Van,John E. Tarpley,P Derby,Richard Lee,William J. Boyle +29 more