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Yinfeng Yang
Researcher at Dalian University of Technology
Publications - 23
Citations - 2796
Yinfeng Yang is an academic researcher from Dalian University of Technology. The author has contributed to research in topics: Docking (molecular) & Quantitative structure–activity relationship. The author has an hindex of 11, co-authored 23 publications receiving 1427 citations. Previous affiliations of Yinfeng Yang include Shihezi University.
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TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.
Jinlong Ru,Peng Li,Wang Jinan,Wei Zhou,Bohui Li,Chao Huang,Pidong Li,Zihu Guo,Weiyang Tao,Yinfeng Yang,Xue Xu,Yan Li,Yonghua Wang,Ling Yang +13 more
TL;DR: The particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature ofTCM theory and developing new herb-oriented drugs.
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Systematic Investigation of Ginkgo Biloba Leaves for Treating Cardio-cerebrovascular Diseases in an Animal Model.
Yinfeng Yang,Yan Li,Jinghui Wang,Ke Sun,Weiyang Tao,Zhenzhong Wang,Wei Xiao,Yanqiu Pan,Shuwei Zhang,Yonghua Wang +9 more
TL;DR: The results show that GBLs exhibit a protective effect on CCVDs probably through regulating multiple pathways and hitting on multiple targets involved in several biological pathways, which will promote the development and application of TCM.
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A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis
Yan Li,Jinghui Wang,Yuanchun Xiao,Yonghua Wang,Su-Shing Chen,Yinfeng Yang,Aiping Lu,Shuwei Zhang +7 more
TL;DR: The results show that the two herbs modulate the angiogenesis mediators through both direct and indirect pathways, and 21 common targets shared by Semen Strychni and TwHF bear major responsibility for treating RA.
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Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
Jingxiao Zhang,Yan Li,Su-Shing Chen,Lilei Zhang,Jinghui Wang,Yinfeng Yang,Shuwei Zhang,Yanqiu Pan,Yonghua Wang,Ling Yang +9 more
TL;DR: The results demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.
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An in silico exploration of the interaction mechanism of pyrazolo[1,5-a]pyrimidine type CDK2 inhibitors
TL;DR: It is anticipated that the binding mechanism and structural features of PHTPP inhibitors studied in the present work will benefit the discovery of more potent CDK2 inhibitors, and the valid pyrazolo[1,5-a]pyrimidine-7-N-yl inhibitors will soon emerge from the large number of screening programmes to enter in clinical studies.