Y
Yong Yu
Researcher at Baylor College of Medicine
Publications - 20
Citations - 1567
Yong Yu is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Caenorhabditis elegans & Proteome. The author has an hindex of 13, co-authored 18 publications receiving 1276 citations. Previous affiliations of Yong Yu include Chinese Academy of Sciences & University of Michigan.
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Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering
TL;DR: In this paper, the authors used stimulated Raman-scattering imaging of alkyne tags as a general strategy for studying a broad spectrum of small biomolecules in live cells and animals.
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Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
Andrew Folick,Holly D. Oakley,Yong Yu,Eric H. Armstrong,Manju Kumari,Lucas Sanor,David D. Moore,Eric A. Ortlund,Rudolf Zechner,Meng C. Wang +9 more
TL;DR: In the worm Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclear translocalization of a lysOSomal lipid chaperone LBP-8, which promoted longevity by activating the nuclear hormone receptors N HR-49 and NHR-80 and promoted longevity in C. elegans.
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Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy
TL;DR: An imaging technique to visualize nascent proteins by harnessing the emerging stimulated Raman scattering (SRS) microscopy coupled with metabolic incorporation of deuterium-labeled amino acids is reported, which can readily generate spatial maps of the quantitative ratio between new and total proteomes.
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C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog
Jie Liu,Alex Ward,Jingwei Gao,Jingwei Gao,Yongming Dong,Nana Nishio,Hitoshi Inada,Hitoshi Inada,Lijun Kang,Yong Yu,Yong Yu,Di Ma,Tao Xu,Ikue Mori,Zhixiong Xie,X.Z. Shawn Xu +15 more
TL;DR: The genetic, pharmacological and electrophysiological data suggest a model in which LITE-1 transduces light signals in ASJ via G protein signaling, which leads to upregulation of the second messenger cGMP, followed by opening of cG MP-sensitive CNG channels and stimulation of photoreceptor cells.
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In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy
Dan Fu,Yong Yu,Andrew Folick,Erin Currie,Robert V. Farese,Tsung-Huang Tsai,Xiaoliang Sunney Xie,Meng C. Wang +7 more
TL;DR: It is found that unsaturated fatty acid has preferential uptake into lipid storage while saturated fatty acid exhibits toxicity in hepatic cells, unlike previously hypothesized.