H
Hanna Kim
Researcher at National Institutes of Health
Publications - 22
Citations - 1728
Hanna Kim is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Juvenile dermatomyositis & Medicine. The author has an hindex of 12, co-authored 16 publications receiving 1211 citations.
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Journal ArticleDOI
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
Scott W. Canna,Adriana Almeida de Jesus,Sushanth Gouni,Stephen R. Brooks,Bernadette Marrero,Yin Liu,Michael A. DiMattia,Kristien J. M. Zaal,Gina A. Montealegre Sanchez,Hanna Kim,Dawn Chapelle,Nicole Plass,Yan Huang,Alejandro V. Villarino,Angelique Biancotto,Thomas A. Fleisher,Joseph A. Duncan,John J. O'Shea,Susanne M. Benseler,Alexei A. Grom,Zuoming Deng,Ronald M. Laxer,Raphaela Goldbach-Mansky +22 more
TL;DR: A new monoallelic inflammasome defect is described that expands the monogenic autoinflammatory disease spectrum to include MAS and suggests new targets for therapy.
Journal ArticleDOI
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Gina A. Montealegre Sanchez,Adam L Reinhardt,Suzanne E. Ramsey,Helmut Wittkowski,Philip J. Hashkes,Yackov Berkun,Susanne Schalm,Sara Murias,Jason Dare,Diane Brown,Deborah L. Stone,Ling Gao,Thomas Klausmeier,Dirk Foell,Adriana Almeida de Jesus,Dawn Chapelle,Hanna Kim,Samantha Dill,Robert A. Colbert,Laura Failla,B. Kost,Michelle O'Brien,James C. Reynolds,Les R. Folio,Katherine R. Calvo,Scott M. Paul,Nargues Weir,Alessandra Brofferio,Ariane Soldatos,Angelique Biancotto,Edward W. Cowen,John J. Digiovanna,Massimo Gadina,Andrew Lipton,Colleen Hadigan,Steven M. Holland,Joseph A. Fontana,Ahmad Samer Alawad,Rebecca J. Brown,Kristina I. Rother,Theo Heller,Kristina M Brooks,Parag Kumar,Stephen R. Brooks,Meryl Waldman,Harsharan K. Singh,Volker Nickeleit,Maria Silk,Apurva Prakash,Jonathan Janes,Seza Ozen,Paul G. Wakim,Paul A. Brogan,William L. Macias,Raphaela Goldbach-Mansky +54 more
TL;DR: Upon baricitinib treatment, clinical manifestations and inflammatory and IFN biomarkers improved in patients with the monogenic interferonopathies CANDLE, SAVI, and other interfer onopathies.
Journal ArticleDOI
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production
Anja Brehm,Yin Liu,Afzal Sheikh,Bernadette Marrero,Ebun Omoyinmi,Qing Zhou,G Montealegre,Angelique Biancotto,Adam L Reinhardt,Adriana Almeida de Jesus,Martin Pelletier,Wanxia L. Tsai,Elaine F. Remmers,Lela Kardava,Suvimol Hill,Hanna Kim,Helen J. Lachmann,André Mégarbané,Jae Jin Chae,Jilian Brady,Rhina D. Castillo,Diane E. Brown,Angel Vera Casano,Ling Gao,Dawn Chapelle,Yan Huang,Deborah L. Stone,Yongqing Chen,Franziska Sotzny,Chyi-Chia Richard Lee,Daniel L. Kastner,Antonio Torrelo,Abraham Zlotogorski,Susan Moir,Massimo Gadina,Phil McCoy,Robert Wesley,Kristina I. Rother,Peter W. Hildebrand,Paul A. Brogan,Elke Krüger,Ivona Aksentijevich,Raphaela Goldbach-Mansky +42 more
TL;DR: Function evaluation revealed that these mutations variably affect transcription, protein expression, protein folding, proteasome assembly, and, ultimately, proteAsome activity, and defects in proteasomesome formation and function were recapitulated by siRNA-mediated knockdown of the respective subunits in primary fibroblasts from healthy individuals.
Journal ArticleDOI
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
Adriana Almeida de Jesus,Yangfeng Hou,Stephen R. Brooks,Louise Malle,Angelique Biancotto,Yan Huang,Katherine R. Calvo,Bernadette Marrero,Susan Moir,Andrew J. Oler,Zuoming Deng,Gina A. Montealegre Sanchez,Amina Ahmed,Eric J. Allenspach,Bita Arabshahi,Edward M. Behrens,Susanne M. Benseler,Liliana Bezrodnik,Sharon Bout-Tabaku,Anne Marie C. Brescia,Diane E. Brown,Jon M. Burnham,María Soledad Caldirola,Ruy Carrasco,Alice Y. Chan,Rolando Cimaz,Paul Dancey,Jason Dare,Marietta DeGuzman,Victoria R. Dimitriades,Ian Ferguson,Polly J. Ferguson,Laura S. Finn,Marco Gattorno,Alexei A. Grom,Eric P. Hanson,Philip J. Hashkes,Christian M. Hedrich,Ronit Herzog,Gerd Horneff,Rita Jerath,Elizabeth A. Kessler,Hanna Kim,Daniel J. Kingsbury,Ronald M. Laxer,Pui Y. Lee,Min Ae Lee-Kirsch,Laura B Lewandowski,Suzanne C. Li,Vibke Lilleby,Vafa Mammadova,Lakshmi N. Moorthy,Gulnara Nasrullayeva,Kathleen M. O'Neil,Karen Onel,Seza Ozen,Nancy Pan,Pascal Pillet,Daniela Gerent Petry Piotto,Marilynn Punaro,Andreas Reiff,Adam L Reinhardt,Lisa G. Rider,Rafael Rivas-Chacon,Tova Ronis,Angela Rösen-Wolff,Johannes Roth,Natasha M. Ruth,Marite Rygg,Heinrike Schmeling,Grant S. Schulert,Christiaan Scott,Gisella Seminario,Andrew I. Shulman,Vidya Sivaraman,Mary Beth F. Son,Yuriy Stepanovskiy,Elizabeth Stringer,Sara Taber,Maria Teresa Terreri,Cynthia J. Tifft,Troy R. Torgerson,Laura L. Tosi,Annet van Royen-Kerkhof,Theresa Wampler Muskardin,Scott W. Canna,Raphaela Goldbach-Mansky +86 more
TL;DR: The IRG-S expands the diagnostic armamentarium in evaluating USAIDs and points to different pathways regulating IRG expression as well as 3 additional autoinflammatory diseases: IL-18-mediated PAP and recurrent MAS, NEMO∆5-associated autoinflammatory syndrome (NEMO-NDAS), and SAMD9L- associated autoinflammatory disease (SAMD 9L-SAAD).
Journal ArticleDOI
Development of a Validated Interferon Score Using NanoString Technology
Hanna Kim,Adriana Almeida de Jesus,Stephen R. Brooks,Yin Liu,Yan Huang,Rachel VanTries,Gina A. Montealegre Sanchez,Yaron Rotman,Massimo Gadina,Raphaela Goldbach-Mansky +9 more
TL;DR: A 28-IFN response gene scoring system is developed to calculate either a standardized or geomean score by customizing a NanoString assay to quantify the expression of putative IRGs and showed high reproducibility and low intra- and interassay variability.