York Posor

TL;DR: It is shown that formation of PI(3,4)P2 by class II phosphatidylinositol-3-kinase C2α (PI(3)K C2 α) spatiotemporally controls clathrin-mediated endocytosis and unravels a novel discrete function of PI (3, 4)P 2 in a central cell physiological process.

TL;DR: This work presents the crystal structure of human dynamin 1 in the nucleotide-free state with a four-domain architecture comprising the GTPase domain, the bundle signalling element, the stalk and the pleckstrin homology domain, and suggests a structural model for the mechanochemical coupling that reconciles previous models of dynamin function.

TL;DR: Current knowledge of the different PI3K classes and isoforms is summarized, focusing on recently uncovered biological functions and the mechanisms by which these kinases are activated.

TL;DR: It is reported that PI3K-C2α is enriched in the pericentriolar recycling endocytic compartment (PRE) at the base of the primary cilium, where it regulates the formation of a PtdIns3P pool at the PRE required for Rab11 and Shh pathway activation.

TL;DR: The mechanisms by which PIs are made and consumed to regulate CME and other endocytic pathways and how conversion of PIs en route to endosomes may be accomplished are provided.