Youxian Li

TL;DR: In this paper, the authors show that centenarians have a distinct gut microbiome that is enriched in microorganisms that are capable of generating unique secondary bile acids, including various isoforms of lithocholic acid (LCA): iso-, 3-oxo-, allo-, 3oxoallo- and isoallolithocholic acids.

TL;DR: In this paper, the authors show that Staphylococcus cohnii is a skin commensal capable of beneficially inhibiting skin inflammation and that S. cohnii colonization is accompanied by activation of host glucocorticoid-related pathways and induction of anti-inflammatory genes in the skin and is therefore effective at suppressing inflammation in diverse pathobiont-independent dermatitis models, including chemically induced, type 17, and type 2 immune-driven models.

TL;DR: The collection of microorganisms living in the mammalian gastrointestinal tract, termed the gut microbiota, has been shown to have profound impacts on host health and increasingly is regarded as a viable therapeutic target as mentioned in this paper.

TL;DR: It is shown that centenarians have a distinct gut microbiome enriched in microbes capable of generating unique secondary bile acids, including iso-, 3-oxo-, and isoallo-lithocholic acid (LCA), as compared to elderly and young controls, and that specific bile acid metabolism may be involved in reducing the risk of pathobiont infection.

TL;DR: This composition for inhibiting trypsin activity contains, as an active ingredient, a bacterium belonging to the genus Paraprevotella as mentioned in this paper, which is a type of bacterium that is known to be resistant to trypsins.