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Wataru Suda
Researcher at Chiba University
Publications - 62
Citations - 1429
Wataru Suda is an academic researcher from Chiba University. The author has contributed to research in topics: Microbiome & Gut flora. The author has an hindex of 14, co-authored 62 publications receiving 703 citations.
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Journal ArticleDOI
Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing
Seok Won Kim,Wataru Suda,Sangwan Kim,Kenshiro Oshima,Shinji Fukuda,Shinji Fukuda,Hiroshi Ohno,Hidetoshi Morita,Masahira Hattori +8 more
TL;DR: Investigating effects of probiotics on human intestinal microbiota using 454 pyrosequencing of bacterial 16S ribosomal RNA genes with an improved quantitative accuracy suggests robustness of the gut microbiota composition in healthy adults on probiotic administration.
Journal ArticleDOI
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Yuko Sato,Koji Atarashi,Damian R. Plichta,Yasumichi Arai,Satoshi Sasajima,Sean M. Kearney,Wataru Suda,Kozue Takeshita,Takahiro Sasaki,Shoki Okamoto,Ashwin N. Skelly,Yuki Okamura,Hera Vlamakis,Youxian Li,Takeshi Tanoue,Hajime Takei,Hiroshi Nittono,Seiko Narushima,Junichiro Irie,Hiroshi Itoh,Kyoji Moriya,Yuki Sugiura,Makoto Suematsu,Nobuko Moritoki,Shinsuke Shibata,Dan R. Littman,Dan R. Littman,Michael A. Fischbach,Yoshifumi Uwamino,Takashi Inoue,Akira Honda,Masahira Hattori,Tsuyoshi Murai,Ramnik J. Xavier,Ramnik J. Xavier,Nobuyoshi Hirose,Kenya Honda +36 more
TL;DR: In this paper, the authors show that centenarians have a distinct gut microbiome that is enriched in microorganisms that are capable of generating unique secondary bile acids, including various isoforms of lithocholic acid (LCA): iso-, 3-oxo-, allo-, 3oxoallo- and isoallolithocholic acids.
Journal ArticleDOI
Gut microorganisms act together to exacerbate inflammation in spinal cords.
Eiji Miyauchi,Seok Won Kim,Wataru Suda,Masami Kawasumi,Satoshi Onawa,Naoko Taguchi-Atarashi,Hidetoshi Morita,Todd D. Taylor,Masahira Hattori,Hiroshi Ohno +9 more
TL;DR: It is shown that two distinct signals from gut microorganisms coordinately activate autoreactive T cells in the small intestine that respond specifically to myelin oligodendrocyte glycoprotein (MOG) after induction of experimental autoimmune encephalomyelitis in mice.
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The liver-brain-gut neural arc maintains the Treg cell niche in the gut.
Toshiaki Teratani,Yohei Mikami,Nobuhiro Nakamoto,Takahiro Suzuki,Yosuke Harada,Koji Okabayashi,Yuya Hagihara,Nobuhito Taniki,Keita Kohno,Shinsuke Shibata,Kentaro Miyamoto,Harumichi Ishigame,Po Sung Chu,Tomohisa Sujino,Wataru Suda,Masahira Hattori,Minoru Matsui,Takaharu Okada,Hideyuki Okano,Masayuki Inoue,Toshihiko Yada,Yuko Kitagawa,Akihiko Yoshimura,Mamoru Tanida,Makoto Tsuda,Yusaku Iwasaki,Takanori Kanai,Takanori Kanai +27 more
TL;DR: It is demonstrated that the novel vago-vagal liver-brain-gut reflex arc tunes the number of pTreg cells and maintains the gut homeostasis, which could help develop new therapeutic strategies to treat or prevent immunological disorders of the gut.
Journal ArticleDOI
Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis.
Daiki Takewaki,Wataru Suda,Wakiro Sato,Lena Takayasu,Naveen Kumar,Kimitoshi Kimura,Naoko Kaga,Toshiki Mizuno,Sachiko Miyake,Masahira Hattori,Takashi Yamamura +10 more
TL;DR: Gut ecological and functional microenvironments were significantly altered in the different stages of MS, and it is postulated that excessive DNA oxidation could take place in the gut of SPMS.