T
Takashi Inoue
Researcher at Central Institute for Experimental Animals
Publications - 89
Citations - 2607
Takashi Inoue is an academic researcher from Central Institute for Experimental Animals. The author has contributed to research in topics: Marmoset & Callithrix. The author has an hindex of 23, co-authored 78 publications receiving 1956 citations. Previous affiliations of Takashi Inoue include RIKEN Brain Science Institute & University of Tokyo.
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Journal ArticleDOI
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
Takeshi Tanoue,Satoru Morita,Damian R. Plichta,Ashwin N. Skelly,Wataru Suda,Wataru Suda,Yuki Sugiura,Seiko Narushima,Hera Vlamakis,Iori Motoo,Kayoko Sugita,Atsushi Shiota,Kozue Takeshita,Keiko Yasuma-Mitobe,Dieter Riethmacher,Tsuneyasu Kaisho,Jason M. Norman,Daniel Mucida,Makoto Suematsu,Tomonori Yaguchi,Vanni Bucci,Takashi Inoue,Yutaka Kawakami,Bernat Olle,Bruce L. Roberts,Masahira Hattori,Masahira Hattori,Ramnik J. Xavier,Ramnik J. Xavier,Koji Atarashi,Kenya Honda +30 more
TL;DR: A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models.
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Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Yuko Sato,Koji Atarashi,Damian R. Plichta,Yasumichi Arai,Satoshi Sasajima,Sean M. Kearney,Wataru Suda,Kozue Takeshita,Takahiro Sasaki,Shoki Okamoto,Ashwin N. Skelly,Yuki Okamura,Hera Vlamakis,Youxian Li,Takeshi Tanoue,Hajime Takei,Hiroshi Nittono,Seiko Narushima,Junichiro Irie,Hiroshi Itoh,Kyoji Moriya,Yuki Sugiura,Makoto Suematsu,Nobuko Moritoki,Shinsuke Shibata,Dan R. Littman,Dan R. Littman,Michael A. Fischbach,Yoshifumi Uwamino,Takashi Inoue,Akira Honda,Masahira Hattori,Tsuyoshi Murai,Ramnik J. Xavier,Ramnik J. Xavier,Nobuyoshi Hirose,Kenya Honda +36 more
TL;DR: In this paper, the authors show that centenarians have a distinct gut microbiome that is enriched in microorganisms that are capable of generating unique secondary bile acids, including various isoforms of lithocholic acid (LCA): iso-, 3-oxo-, allo-, 3oxoallo- and isoallolithocholic acids.
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Zic2 Controls Cerebellar Development in Cooperation with Zic1
Jun Aruga,Takashi Inoue,Takashi Inoue,Jun Hoshino,Jun Hoshino,Katsuhiko Mikoshiba,Katsuhiko Mikoshiba +6 more
TL;DR: In this article, it was shown that Zic2 and Zic1 cooperatively control cerebellar development by regulating neuronal differentiation, and showed that these two genes encode zinc finger proteins and are expressed in the developing and mature CNS.
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Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.
Kenya Sato,Ryo Oiwa,Wakako Kumita,Rachel Henry,Tetsushi Sakuma,Ryoji Ito,Ryoko Nozu,Takashi Inoue,Ikumi Katano,Kengo Sato,Norio Okahara,Junko Okahara,Yoshihisa Shimizu,Yamamoto Masafumi,Kisaburo Hanazawa,Takao Kawakami,Yoshie Kametani,Ryuji Suzuki,Takeshi Takahashi,Edward J. Weinstein,Takashi Yamamoto,Yasubumi Sakakibara,Sonoko Habu,Jun-ichi Hata,Hideyuki Okano,Erika Sasaki,Erika Sasaki +26 more
TL;DR: This study optimized zinc-finger nucleases and transcription activator-like effector nucleases to target interleukin-2 receptor subunit gamma (IL2RG) in pronuclear stage marmoset embryos and demonstrates highly efficient production of founder NHP with SCID phenotypes.
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Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.
Emi Kinameri,Takashi Inoue,Jun Aruga,Itaru Imayoshi,Ryoichiro Kageyama,Tomomi Shimogori,Adrian W. Moore +6 more
TL;DR: The data demonstrate that Prdm genes are regulated by the Notch-Hes pathway and represent strong candidates to control neural class specification and the sequential progression of mammalian CNS neurogenesis.