Yu Hsuan Lin

TL;DR: It is shown that eIF2α-phosphorylation-attenuated protein synthesis, and not Atf4 mRNA translation, promotes cell survival, and suggesting that limiting protein synthesis will be therapeutic for diseases caused by protein misfolding in the ER.

TL;DR: This work presents a peak-calling prioritization pipeline (PePr) for identifying consistent or differential binding sites in ChIP-Seq experiments with biological replicates and shows that PePr uniquely identifies consistent regions with enriched read counts, high motif occurrence rate and known characteristics of TF binding based on visual inspection.

TL;DR: By surveying large swaths of DNA surrounding the Gata3 locus, this work located a cis element that can recapitulate aspects of the GATA3-dependent T cell regulatory program in vivo, and directs both T cell- and NK cell-specific transcription in vivo but harbors no other tissue activity.

TL;DR: This study will serve as a comprehensive platform for future in-depth investigation of human erythroid development that, in turn, may reveal new insights into multiple layers of the transcriptional regulatory hierarchy that controls erythropoiesis.

TL;DR: The first genome-wide identification and characterization of TR4 in vivo binding and the identification of cell type specific TR4 binding sites enables future studies of the pathways underlying TR4 action and its possible role in metabolic diseases.