J
Jonathon N. Winnay
Researcher at Harvard University
Publications - 40
Citations - 7939
Jonathon N. Winnay is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin receptor & Insulin resistance. The author has an hindex of 30, co-authored 40 publications receiving 7197 citations. Previous affiliations of Jonathon N. Winnay include Joslin Diabetes Center & Brigham and Women's Hospital.
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Journal ArticleDOI
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
Jens C. Brüning,M. Dodson Michael,Jonathon N. Winnay,Tatsuya Hayashi,Dieter Hörsch,Domenico Accili,Laurie J. Goodyear,C. Ronald Kahn +7 more
TL;DR: Insulin resistance in muscle contributes to the altered fat metabolism associated with type 2 diabetes, but tissues other than muscle appear to be more involved in insulin-regulated glucose disposal than previously recognized.
Journal ArticleDOI
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
Rohit N. Kulkarni,Jens C. Brüning,Jonathon N. Winnay,Catherine Postic,Mark A. Magnuson,C R Kahn +5 more
TL;DR: An important functional role for the insulin receptor in glucose sensing by the pancreatic beta cell is indicated and it is suggested that defects in insulin signaling at the level of the beta cell may contribute to the observed alterations in insulin secretion in type 2 diabetes.
Journal ArticleDOI
Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomas Thomou,Marcelo A. Mori,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Masahiro Konishi,Masaji Sakaguchi,Christian Wolfrum,Tata Nageswara Rao,Tata Nageswara Rao,Jonathon N. Winnay,Ruben Garcia-Martin,Steven K. Grinspoon,Phillip Gorden,C. Ronald Kahn +13 more
TL;DR: Transplantation of both white and brown adipose tissue—brown especially—into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.
Journal ArticleDOI
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Yu-Hua Tseng,Efi Kokkotou,Tim J. Schulz,Tian Lian Huang,Jonathon N. Winnay,Cullen M. Taniguchi,Thien T. Tran,Ryo Suzuki,Daniel Espinoza,Yuji Yamamoto,Molly J. Ahrens,Andrew T. Dudley,Andrew W. Norris,Rohit N. Kulkarni,C. Ronald Kahn +14 more
TL;DR: It is demonstrated that whereas some members of the family of bone morphogenetic proteins (BMPs) support white adipocyte differentiation, BMP7 singularly promotes differentiation of brown preadipocytes even in the absence of the normally required hormonal induction cocktail.
Journal ArticleDOI
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.
Jens C. Brüning,Jonathon N. Winnay,Susan Bonner-Weir,Simeon I. Taylor,Domenico Accili,C. Ronald Kahn +5 more
TL;DR: This NIDDM mouse model in which diabetes arises in an age-dependent manner from the interaction between two genetically determined, subclinical defects in the insulin signaling cascade demonstrates the role of epistatic interactions in the pathogenesis of common diseases with non-Mendelian genetics.