Yuancheng Lu

TL;DR: It is shown that SIRT1 in endothelial cells is a key mediator of pro-angiogenic signals secreted from myocytes and has implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the elderly.

TL;DR: Using the eye as a model CNS tissue, ectopic expression of Oct4, Sox2 and Klf4 genes (OSK) in mouse retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice.

TL;DR: It is shown here that SIRT1 in endothelial cells is a key mediator of pro-angiogenic signals secreted from myocytes that have implications for improving blood flow to organs and tissues, increasing performance, and reestablishing a virtuous cycle of mobility in aged individuals.

TL;DR: This work shows that expression of Oct4, Sox2, and Klf4 genes in mice resets youthful gene expression patterns and the DNA methylation age of retinal ganglion cells, promotes axon regeneration after optic nerve crush injury, and restores vision in a mouse model of glaucoma and in normal old mice.

TL;DR: Methods for identifying and characterizing STACs are described, including production of recombinantprotein, in vitro assays with recombinant protein, and cellular assays based on mitochondrial dynamics.