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Yulin Ouyang
Researcher at University of Liverpool
Publications - 5
Citations - 155
Yulin Ouyang is an academic researcher from University of Liverpool. The author has contributed to research in topics: Mitochondrial permeability transition pore & Mitochondrion. The author has an hindex of 2, co-authored 5 publications receiving 112 citations. Previous affiliations of Yulin Ouyang include Royal Liverpool University Hospital.
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Journal ArticleDOI
Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release.
Wei Huang,Wei Huang,Wei Huang,Matthew C Cane,Rajarshi Mukherjee,Rajarshi Mukherjee,Peter Szatmary,Peter Szatmary,Xiaoying Zhang,Xiaoying Zhang,Victoria Elliott,Yulin Ouyang,Yulin Ouyang,Michael Chvanov,Michael Chvanov,Diane Latawiec,Li Wen,Li Wen,David Booth,Andrea C. Haynes,Ole H. Petersen,Alexei V. Tepikin,David N. Criddle,David N. Criddle,Robert Sutton +24 more
TL;DR: Caffeine and its dimethylxanthine metabolites reduced pathological IP3R-mediated pancreatic acinar Ca2+ signals but only caffeine ameliorated experimental AP.
Journal ArticleDOI
Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
Jane A Armstrong,Nicole Cash,Yulin Ouyang,Jack C Morton,Michael Chvanov,Diane Latawiec,Muhammad Awais,Alexei V. Tepikin,Robert Sutton,David N. Criddle +9 more
TL;DR: Results indicate that oxidative stress alters mitochondrial bioenergetics and modifies pancreatic acinar cell death, and a shift from apoptosis to necrosis appears to be associated with decreased mitochondrial spare respiratory capacity and ATP production.
Journal ArticleDOI
Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does not Reduce Severity of Experimental Acute Pancreatitis
Michael Chvanov,Svetlana Voronina,Xiaoying Zhang,Svetlana Telnova,Robert Chard,Yulin Ouyang,Jane A Armstrong,Helen Tanton,Muhammad Awais,Diane Latawiec,Robert Sutton,David N. Criddle,Alexei V. Tepikin +12 more
TL;DR: It is found that pancreatic acinar cells from MCU−/− mice display dramatically reduced mitochondrial Ca2+ uptake, consistent with the drastic changes of stimulus-metabolism coupling, manifested by the reduction of mitochondrial NADH/FAD+ responses to cholecystokinin and in the decrease of chole Cy2+-stimulated oxygen consumption.
Journal ArticleDOI
Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1.
Yulin Ouyang,Li Wen,Jane A Armstrong,Michael Chvanov,Diane Latawiec,Wenhao Cai,Mohammad Awais,Rajarshi Mukherjee,Wei Huang,Peter J. Gough,John Bertin,Alexei V. Tepikin,Robert Sutton,David N. Criddle +13 more
TL;DR: In this article, the effects of RIPK1 inhibitor Necrostatin-1 (Nec-1) and RIPK 1K45A modification (RIPK 1 K45A: kinase dead) in bile acid (TLCS-AP), alcoholic (FAEE-AP) and caerulein hyperstimulation (CER-AP).
Posted ContentDOI
Untargeted 1H NMR Metabolomics and Pathway Analysis Reveals Dysregulated Proteostasis in Cyclophilin D (CypD)-deficient Mice Tissues
TL;DR: In this article, the role of cyclophilin D (CypD) in maintaining protein homeostasis was investigated in mice with and without the CypD gene, with data from the serum to identify systematic changes.