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Yupeng Qiu
Researcher at Johns Hopkins University
Publications - 16
Citations - 768
Yupeng Qiu is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Helicase & RNA. The author has an hindex of 6, co-authored 16 publications receiving 574 citations. Previous affiliations of Yupeng Qiu include Duke University & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
mRNA structure determines specificity of a polyQ-driven phase separation
Erin M Langdon,Yupeng Qiu,Amirhossein Ghanbari Niaki,Grace A. McLaughlin,Chase A. Weidmann,Therese M. Gerbich,Jean A. Smith,John M. Crutchley,Christina M. Termini,Kevin M. Weeks,Sua Myong,Amy S. Gladfelter,Amy S. Gladfelter +12 more
TL;DR: The shape of RNA can promote the formation and coexistence of the diverse array of RNA-rich liquid compartments found in a single cell and support a model in which structure-based, RNA-RNA interactions promote assembly of distinct droplets and protein-driven, conformational dynamics of the RNA maintain this identity.
Journal ArticleDOI
Ultrasonic Viscoelasticity Imaging of Nonpalpable Breast Tumors: Preliminary Results
TL;DR: Characterization of nonpalpable breast lesions is improved by the addition of viscoelastic strain imaging parameters, and the differentiation of malignant and benign BI-RADS 4 or 5 tumors is especially evident with the use of the retardation time estimates, T(1).
Journal ArticleDOI
Srs2 prevents Rad51 filament formation by repetitive motion on DNA.
TL;DR: A single-molecule fluorescence study of the dynamics of Rad51 filament formation and its disruption by SRS2 reveals an exquisite and highly specific mechanism by which Srs2 regulates the Rad51 filaments formation.
Posted ContentDOI
mRNA structure determines specificity of a polyQ-driven phase separation
Erin M Langdon,Yupeng Qiu,Amirhossein Ghanbari Niaki,Grace A. McLaughlin,Chase A. Weidmann,Therese M. Gerbich,Jean A. Smith,John M. Crutchley,Christina M. Termini,Kevin M. Weeks,Sua Myong,Amy S. Gladfelter +11 more
TL;DR: It is found that the specific secondary structure of a cyclin mRNA is required for it to assemble into distinct droplets and be excluded from other droplets containing functionally-unrelated mRNAs.
Journal ArticleDOI
The Chd1 Chromatin Remodeler Shifts Nucleosomal DNA Bidirectionally as a Monomer.
Yupeng Qiu,Yupeng Qiu,Robert F Levendosky,Srinivas Chakravarthy,Ashok Kumar Patel,Gregory D. Bowman,Sua Myong,Sua Myong +7 more
TL;DR: It is demonstrated that the monomeric Chd1 remodeler shifts DNA back and forth by dynamically alternating between different segments of the nucleosome, and proposed that active interplay of the ATPase motor with the regulatory domains may promote dynamic nucleosomes structures uniquely suited for histone exchange and chromatin reorganization during transcription.