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Yutaka Shimada
Researcher at University of Toyama
Publications - 445
Citations - 15929
Yutaka Shimada is an academic researcher from University of Toyama. The author has contributed to research in topics: Cancer & Esophageal cancer. The author has an hindex of 58, co-authored 441 publications receiving 14980 citations. Previous affiliations of Yutaka Shimada include Kyoto University & Niigata University.
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Journal ArticleDOI
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
David M. Berman,Sunil S. Karhadkar,Anirban Maitra,Rocío Montes de Oca,Meg R. Gerstenblith,Kimberly J. Briggs,Antony R. Parker,Yutaka Shimada,James R. Eshleman,D. Neil Watkins,Philip A. Beachy +10 more
TL;DR: A wide range of digestive tract tumours, including most of those originating in the oesophagus, stomach, biliary tract and pancreas, but not in the colon, display increased Hh pathway activity, which is suppressible by cyclopamine, a Hh pathways antagonist.
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Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44
Shigeo Takaishi,Tomoyuki Okumura,Tomoyuki Okumura,Shuiping Tu,Sophie S.W. Wang,Sophie S.W. Wang,Wataru Shibata,Ramanathan Vigneshwaran,Shanisha A. Gordon,Yutaka Shimada,Timothy C. Wang +10 more
TL;DR: The existence of gastric CSCs is identified from a panel of human gastric cancer cell lines using cell surface marker CD44 and these cells showed the stem cell properties of self‐renewal and the ability to form differentiated progeny and gave rise to CD44(−) cells.
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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
Rika Hoshino,Yuji Chatani,Takao Yamori,Takashi Tsuruo,Takashi Tsuruo,Hiroya Oka,Osamu Yoshida,Yutaka Shimada,Shigeki Arii,Hiromi Wada,Jiro Fujimoto,Michiaki Kohno +11 more
TL;DR: The results suggest that the constitutive activation of 41-/43-kDa MAP kinases in tumor cells is not due to the disorder of MAP kinase themselves, but is due toThe disorder of Raf-1, Ras, or some other signaling molecules upstream of Ras.
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Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus: a Japan Clinical Oncology Group Study--JCOG9204.
Nobutoshi Ando,Toshifumi Iizuka,Hiroko Ide,Kaoru Ishida,Masayuki Shinoda,Tadashi Nishimaki,Wataru Takiyama,Hiroshi Watanabe,Kaichi Isono,Norio Aoyama,Hiroyasu Makuuchi,Otsuo Tanaka,Hideaki Yamana,Shunji Ikeuchi,Toshiyuki Kabuto,Kagami Nagai,Yutaka Shimada,Yoshihide Kinjo,Haruhiko Fukuda +18 more
TL;DR: Postoperative adjuvant chemotherapy with cisplatin and fluorouracil is better able to prevent relapse in patients with esophageal cancer than surgery alone.
Journal ArticleDOI
Characterization of 21 newly established esophageal cancer cell lines
TL;DR: These cell lines are the first reported to be homogeneous and individually unique and may provide a useful model for the study of human esophageal cancer.