T
Tomohisa Sujino
Researcher at Keio University
Publications - 68
Citations - 989
Tomohisa Sujino is an academic researcher from Keio University. The author has contributed to research in topics: Medicine & Ulcerative colitis. The author has an hindex of 14, co-authored 45 publications receiving 630 citations. Previous affiliations of Tomohisa Sujino include Saitama Medical University & Japan Agency for Medical Research and Development.
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Journal ArticleDOI
A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients.
Kozue Takeshita,Shinta Mizuno,Yohei Mikami,Tomohisa Sujino,Keiichiro Saigusa,Katsuyoshi Matsuoka,Makoto Naganuma,Tadashi Sato,Toshihiko Takada,Hirokazu Tsuji,Akira Kushiro,Koji Nomoto,Takanori Kanai +12 more
TL;DR: Findings suggest that the recovery of homeostasis in the intestinal microbiota could cure inflammatory bowel disease through translational research by analysis of ulcerative colitis patients' intestinal microbiota and clarify the effects of them on inflammation.
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The liver-brain-gut neural arc maintains the Treg cell niche in the gut.
Toshiaki Teratani,Yohei Mikami,Nobuhiro Nakamoto,Takahiro Suzuki,Yosuke Harada,Koji Okabayashi,Yuya Hagihara,Nobuhito Taniki,Keita Kohno,Shinsuke Shibata,Kentaro Miyamoto,Harumichi Ishigame,Po Sung Chu,Tomohisa Sujino,Wataru Suda,Masahira Hattori,Minoru Matsui,Takaharu Okada,Hideyuki Okano,Masayuki Inoue,Toshihiko Yada,Yuko Kitagawa,Akihiko Yoshimura,Mamoru Tanida,Makoto Tsuda,Yusaku Iwasaki,Takanori Kanai,Takanori Kanai +27 more
TL;DR: It is demonstrated that the novel vago-vagal liver-brain-gut reflex arc tunes the number of pTreg cells and maintains the gut homeostasis, which could help develop new therapeutic strategies to treat or prevent immunological disorders of the gut.
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RORγt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation.
TL;DR: Recent advances in the study of Th17 cells, which produce Th17 family cytokines, are reviewed, which may be critically involved in the initiation and persistence of IBD.
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CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice
Keita Saeki,Takanori Kanai,Masaru Nakano,Yuji Nakamura,Naoteru Miyata,Tomohisa Sujino,Yoshiyuki Yamagishi,Hirotoshi Ebinuma,Hiromasa Takaishi,Yuuichi Ono,Kazuyoshi Takeda,Shigenari Hozawa,Akihiko Yoshimura,Toshifumi Hibi +13 more
TL;DR: Cerulein induction of pancreatitis in mice involves migration of CD11b(high)CD11c(-)Gr-1(low) macrophage from the bone marrow (mediated by CCL2 via CCR2 and suppressor of cytokine signaling 3-dependent activation of macrophages), which might lead to new therapeutic strategies for acute pancreatitis.
Journal ArticleDOI
Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells
Tomohisa Sujino,Takanori Kanai,Yuichi Ono,Yohei Mikami,Atsushi Hayashi,Tomomitsu Doi,Katsuyoshi Matsuoka,Tadakazu Hisamatsu,Hiromasa Takaishi,Haruhiko Ogata,Akihiko Yoshimura,Dan R. Littman,Toshifumi Hibi +12 more
TL;DR: Th17 and Th17/Th1 cells become colitogenic alternative Th1 cells via Th17, Th17 /Th1, and Th1-like cells, independently of classical Th 1 cells.