Y
Yvonne Tay
Researcher at National University of Singapore
Publications - 50
Citations - 16319
Yvonne Tay is an academic researcher from National University of Singapore. The author has contributed to research in topics: microRNA & Competing endogenous RNA. The author has an hindex of 22, co-authored 43 publications receiving 13102 citations. Previous affiliations of Yvonne Tay include Agency for Science, Technology and Research & Harvard University.
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Journal ArticleDOI
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
TL;DR: It is proposed that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
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The multilayered complexity of ceRNA crosstalk and competition
TL;DR: Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
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A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes
Kevin Charles Miranda,Tien Huynh,Yvonne Tay,Yen-Sin Ang,Wai Leong Tam,Andrew M. Thomson,Bing Lim,Bing Lim,Isidore Rigoutsos +8 more
TL;DR: Rna22 as discussed by the authors identifies microRNA binding sites and their corresponding heteroduplexes, and then identifies the targeting microRNAs by finding putative microRN binding sites in the sequence of interest.
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MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
TL;DR: The findings demonstrate the abundance of CDS-located miRNA targets, some of which can be species-specific, and support an augmented model whereby animal miRNAs exercise their control on mRNAs through targets that can reside beyond the 3′ untranslated region.
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Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
Yvonne Tay,Lev Kats,Leonardo Salmena,Dror Weiss,Shen Mynn Tan,Shen Mynn Tan,Ugo Ala,Ugo Ala,Florian A. Karreth,Laura Poliseno,Paolo Provero,Ferdinando Di Cunto,Judy Lieberman,Judy Lieberman,Isidore Rigoutsos,Pier Paolo Pandolfi +15 more
TL;DR: This study identified and validated endogenous protein-coding transcripts that regulate PTEN, antagonize PI3K/AKT signaling, and possess growth- and tumor-suppressive properties and presents a road map for the prediction and validation of ceRNA activity and networks and thus imparts a trans-regulatory function to protein- coding mRNAs.