Shen Mynn Tan

TL;DR: This study identified and validated endogenous protein-coding transcripts that regulate PTEN, antagonize PI3K/AKT signaling, and possess growth- and tumor-suppressive properties and presents a road map for the prediction and validation of ceRNA activity and networks and thus imparts a trans-regulatory function to protein- coding mRNAs.

TL;DR: This study genetically identifies multiple putative microRNA decoys for PTEN, validates Z EB2 mRNA as a bona fide PTEN ceRNA, and demonstrates that abrogated ZEB2 expression cooperates with BRAF V600E to promote melanomagenesis.

TL;DR: A genome-wide siRNA lethality screen compared two human breast epithelial cell lines transformed with the same genes to identify basal-like TNBC dependencies, and expression of the screen's 154 BPLER dependency genes correlated with poor prognosis in breast, but not lung or colon, cancer.

TL;DR: An unbiased sequencing-based systems approach is applied to characterize miR-522, a member of the oncogenic primate-specific chromosome 19 miRNA cluster, highly expressed in poorly differentiated cancers and suggested that it regulates cell proliferation, detachment, migration, and epithelial-mesenchymal transition.

TL;DR: It is found that miR-638 overexpression promotes tumorigenesis and cooperativity between miR -638 and its host gene Dnm2 is demonstrated, suggesting that the Dnm1 locus encodes two distinct oncogenic components that play important roles in tumorsigenesis.