Zachary Brown

TL;DR: It is reported that, on cold exposure, brown adipose tissue (BAT) actively utilizes BCAA in the mitochondria for thermogenesis and promotes systemic BCAA clearance in mice and humans and suggests that BAT serves as a key metabolic filter that controls BCAA cleared via SLC25A44, thereby contributing to the improvement of metabolic health.

TL;DR: The mouse develops a developmentally and functionally distinct, non-canonical beige fat cell type as an adaptation to cold ambient temperature that recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival.

TL;DR: A unique subset of adipocyte progenitor cells that possessed the cell-intrinsic plasticity to give rise to beige fat is identified and it is suggested that CD81 functions as a key sensor of external inputs and controls beige APC proliferation and whole-body energy homeostasis.

TL;DR: It is found that increased circulating levels of PLTP, via systemic or BAT‐specific overexpression, significantly improve glucose tolerance and insulin sensitivity, increased energy expenditure, and decrease the circulate levels of cholesterol, phospholipids, and sphingoipids.

TL;DR: The role of SLC25A44, a recently identified mitochondrial BCAA carrier, in the regulation of mitochondrial catabolism and adaptive response to fever in rodents was investigated in this article.