Z
Zanxian Xia
Researcher at Central South University
Publications - 27
Citations - 2517
Zanxian Xia is an academic researcher from Central South University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 10, co-authored 19 publications receiving 1693 citations.
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Journal ArticleDOI
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China.
Aiping Wu,Yousong Peng,Baoying Huang,Xiao Ding,Xianyue Wang,Peihua Niu,Jing Meng,Zhaozhong Zhu,Zheng Zhang,Jiangyuan Wang,Jie Sheng,Lijun Quan,Zanxian Xia,Wenjie Tan,Genhong Cheng,Taijiao Jiang +15 more
TL;DR: An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-n coV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
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Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.
Junjie Zhang,Jun Zhao,Simin Xu,Junhua Li,Shanping He,Yi Zeng,Linshen Xie,Na Xie,Ting Liu,Katie Lee,Gil Ju Seo,Lin Chen,Alex C. Stabell,Zanxian Xia,Sara L. Sawyer,Jae U. Jung,Canhua Huang,Pinghui Feng +17 more
TL;DR: It is reported that variation of a single amino acid residue in the innate immune sensor cGAS determines species-specific inactivation by HSV-1, and a single asparagine in human and mouse cG AS that is not conserved in many non-human primates is identified.
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A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation
Jun Zhao,Yi Zeng,Simin Xu,Jie Chen,Jie Chen,Guobo Shen,Caiqun Yu,David M. Knipe,Weiming Yuan,Jian Peng,Wenqing Xu,Chao Zhang,Zanxian Xia,Pinghui Feng +13 more
TL;DR: It is reported here that UL37 of herpes simplex virus 1 (HSV-1) is a protein deamidase that targets RIG-I to block RNA-induced activation and restrict viral replication.
Journal ArticleDOI
Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2.
Ashuai Du,Rong Zheng,Cyrollah Disoma,Shiqin Li,Zongpeng Chen,Sijia Li,Pinjia Liu,Yuzheng Zhou,Yilun Shen,Sixu Liu,Yongxing Zhang,Zijun Dong,Qinglong Yang,Moyed Alsaadawe,Aroona Razzaq,Yuyang Peng,Xuan Chen,Liqiang Hu,Jian Peng,Qianjun Zhang,Taijiao Jiang,Long Mo,Shanni Li,Zanxian Xia +23 more
TL;DR: Wang et al. as mentioned in this paper reported that epigallocatechin-3-gallate (EGCG), an active ingredient of Chinese herbal medicine (CHM), is a potent inhibitor of 3CLpro with half-maximum inhibitory concentration (IC50) of 0.874± 0.005μM.
Journal ArticleDOI
Zika virus-spread, epidemiology, genome, transmission cycle, clinical manifestation, associated challenges, vaccine and antiviral drug development
Paul Pielnaa,Moyed Alsaadawe,Adonira Saro,Marcelllin Faniriantsoahenrio Dama,Mei Zhou,Yanxia Huang,Jufang Huang,Zanxian Xia +7 more
TL;DR: The past and present spread of ZIKV outbreak-2007-2019, the genome, transmission cycle, clinical manifestations, vaccine and antiviral drug advancement are summarized.