A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation
Jun Zhao,Yi Zeng,Simin Xu,Jie Chen,Jie Chen,Guobo Shen,Caiqun Yu,David M. Knipe,Weiming Yuan,Jian Peng,Wenqing Xu,Chao Zhang,Zanxian Xia,Pinghui Feng +13 more
Reads0
Chats0
TLDR
It is reported here that UL37 of herpes simplex virus 1 (HSV-1) is a protein deamidase that targets RIG-I to block RNA-induced activation and restrict viral replication.About:
This article is published in Cell Host & Microbe.The article was published on 2016-12-14 and is currently open access. It has received 82 citations till now. The article focuses on the topics: RIG-I & Deamidation.read more
Citations
More filters
Journal ArticleDOI
RIG-I-like receptors: their regulation and roles in RNA sensing
Jan Rehwinkel,Michaela U. Gack +1 more
TL;DR: How members of the RLR family are regulated is explained and the importance of the RLRs in viral infection, autoimmunity and cancer is reflected on.
Journal ArticleDOI
Ten Strategies of Interferon Evasion by Viruses.
TL;DR: This Review examines the ten most common strategies that viruses use to subvert the IFN response with examples from publications appearing in the last 10 years of Cell Host & Microbe.
Journal ArticleDOI
Intracellular sensing of viral genomes and viral evasion.
TL;DR: Key regulators of cytosolic sensor proteins and viral proteins are discussed based on experimental evidence, and rapid advances in scientists’ understanding of sensor-mediated antiviral responses at the molecular level are summarized to help guide the development of novel vaccines and antiviral agents.
Journal ArticleDOI
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Morgan E. Brisse,Hinh Ly +1 more
TL;DR: The similarities and differences between RIG-I and MDA5 are discussed from multiple perspectives, including their structures, evolution and functional relationships with other cellular proteins, their differential mechanisms of distinguishing between host and viral dsRNAs and interactions with host and virus protein factors, and their immunogenic signaling.
Journal ArticleDOI
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.
Junjie Zhang,Jun Zhao,Simin Xu,Junhua Li,Shanping He,Yi Zeng,Linshen Xie,Na Xie,Ting Liu,Katie Lee,Gil Ju Seo,Lin Chen,Alex C. Stabell,Zanxian Xia,Sara L. Sawyer,Jae U. Jung,Canhua Huang,Pinghui Feng +17 more
TL;DR: It is reported that variation of a single amino acid residue in the innate immune sensor cGAS determines species-specific inactivation by HSV-1, and a single asparagine in human and mouse cG AS that is not conserved in many non-human primates is identified.
References
More filters
Journal ArticleDOI
Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
Journal ArticleDOI
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
Journal ArticleDOI
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
TL;DR: The identification of a novel protein termed MAVS (mitochondrial antiviral signaling), which mediates the activation of NF-kappaB and IRF 3 in response to viral infection, and implicates a new role of mitochondria in innate immunity.
Journal ArticleDOI
Recognition of microorganisms and activation of the immune response.
TL;DR: The mammalian immune system has innate and adaptive components, which cooperate to protect the host against microbial infections, and recent progress brings us closer to an integrated view of the immune system and its function in host defence.
Journal ArticleDOI
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Taro Kawai,Ken Takahashi,Ken Takahashi,Shintaro Sato,Cevayir Coban,Himanshu Kumar,Hiroki Kato,Ken Ishii,Osamu Takeuchi,Shizuo Akira +9 more
TL;DR: IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection and blocked interferon induction by virus infection.